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Mechanism of pathological angiogenesis in adipose tissue and tumor
(2009-09-18)
Angiogenesis is critical for both malignant diseases, such as cancer, and non-malignant diseases, such as obesity and metabolic disorders. Majority of tissues and organs are highly vascularized. The malfunctions of tissue ...
Immunological studies on anca-associated vasculitis with special reference to T cell activation
(2009-10-16)
This thesis focuses on the role of T cells in ANCA-associated vasculitis. We initially investigated activation markers on T cells in patients with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and renal ...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
The syndecans are a four-member family of type I transmembrane proteoglycans. Their core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan ...
Dermal exposure determinants : a pesticide exposure assessment approach for developing countries
(2008-11-26)
Background: We know little about the levels of exposure to pesticide in
subsistence farmers mainly because of lack of easy to use and low cost
pesticide exposure assessment methods.
Aim: This thesis aimed to develop ...
Recurrent laryngeal nerve injury
(2008-09-05)
Injury to the recurrent laryngeal nerve is accompanied by a poor functional recovery of the target organ, the larynx. For the patient this means impairments of vocal fold mobility and various kinds of voice disorders. In ...
On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate
(2008-05-15)
histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. In this way, DNA can be tightly packaged in the cell. The N-terminal tails, that protrude out from the histone surfaces can be subjected to different covalent...
On angiogenesis modulation
(2009-08-28)
of the resulting vascular plexus; iii) how sixteen genes and twenty-eight compounds modulating angiogenesis were identified, and a role for the serine/threonine (S/T) phosphatases PPP1CA, PPP1CC, and PPP4C was uncovered using – for the first time in vertebrates – a...
Making motherhood safe in the West Bank, occupied Palestinian territory
(2008-05-23)
Objective: To determine causes of death among women of reproductive age; to determine MMR; to review death notification and registration procedures, and to examine the fate and status of under-5 motherless orphans in the ...
HIV-1 genotype and vertical transmission in northern Vietnam
(2008-10-28)
-1 transmission rate to the children in our study was 6.7% with a rate of pre-partum transmission of 4.2% and intra-partum transmission of 1.5%. About 60% of the HIV-1 infected mothers received one dose of nevirapine at labor. The children were...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...