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The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells
(2008-09-04)
The tumor suppressor p53 is a critical regulator of life and death in
cells. The p53 protein is present at very low levels in cells under
normal conditions but accumulates in response to different stress
stimuli, such ...
Mathematical modelling of insulin signalling : effects on glucose metabolism in skeletal muscle
(2010-04-13)
The use of models to understand complex phenomena is indispensable to the
scientific community. The advantage of a model is that it simplifies the
phenomena under study. However, a model should be only as complex ...
Regulation and function of thioredoxin reductase 1 in human tumor cells
(2009-05-22)
The thioredoxin system is a general protein disulfide reductase system
present in all organisms. Its function is to maintain an intracellular
reducing environment and upholding a defense against reactive oxygen
species ...
Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
It has been almost 30 years since the identification of HIV as the causative agent of AIDS. Despite considerable efforts to halt the spread of the virus, the epidemic continues in many parts of the world. The most efficient ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation
(2008-12-26)
Currently, big efforts in HIV-1 research are devoted to the design of a
HIV-1 vaccine. However, no successful vaccine is yet available, also due
to the lack of basic knowledge in HIV-1 pathogenesis which is still
profound. ...
Blocking interleukin-1 signalling in the brain-structural and functional outcomes
(2008-10-07)
The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist...
Aprotinin for reduction of bleeding and transfusions in patients on clopidogrel undergoing urgent coronary surgery
(2009-05-08)
during 1 year (n=33). 18 patients received a full-dose aprotinin, 15 patients served as a control group. II. 75 consecutive patients with unstable angina, administered clopidogrel <5 days before coronary surgery, were randomized to full-dose aprotinin (n...
Apolipoprotein CIII and Ljungan virus in diabetes
(2010-05-05)
It has been shown that there are patients with type 1 diabetes (T1D), whose sera induce an increased activity of voltage-gated Ca2+-channels in pancreatic beta-cells, resulting in increased cytoplasmic free Ca2+ concentration ([Ca2+]i) and apoptosis...
Studies on hereditary spastic paraplegia proteins
(2010-05-14)
different HSP proteins: atlastin-1, a member of the dynamin superfamily of large GTPases through sequence similarity, and maspardin Mast syndrome, spastic paraplegia, autosomal recessive with dementia. Mutations in the atlastin-1 gene, SPG3A, are the second...