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Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition
(2009-02-06)
Diabetes mellitus (DM) is associated with increased cardiovascular
morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one
of the factors that may cause platelet dysfunction in diabetic patients.
This ...
Epigenic regulation and posttranslational modification of human cytochrome P450s : focus on CYP2W1, CYP1A2 and CYP2C18
(2008-11-21)
The cytochrome P450 superfamily represents a very important group of
enzymes that are responsible for the metabolism of drugs as well as of
endogenous compounds. Many P450s are genetically polymorphic causing
important ...
Utility of bispectral index (BIS) monitoring during general anesthesia
(2009-11-12)
The possibility to objectively measure effects from anesthetics on the level of consciousness has since long been desired. General anesthetics cause changes in brain electrical activity, seen as changes in the electroencephalogram ...
Self-reported fecal incontinence and quality of life among gynecological cancer survivors
(2010-05-07)
Gastrointestinal symptoms following pelvic radiotherapy are common;
however, selfreported descriptions of gastrointestinal symptoms and their
impact on daily life among gynecological cancer survivors are rare in ...
New apheresis techniques in transplantation
(2008-11-21)
The shortage of organs for transplantation is a global problem and therefore it is of outmost importance to increase the number of donations and improve long term graft survival. As an effort to increase kidney donations, ...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around ...
Influence of renal dysfunction on therapy and prognosis in patients with myocardial infarction
(2010-04-30)
) ml/min/1.73 m2 and 33% had at least moderate renal dysfunction. Patients with lower renal function differed by being older and having more co-morbidities. They presented less often with chest pain and ST-elevation MI. After adjustments, lower renal...
Aspects of the etiology and survival of lower gastrointestinal cancers
(2010-02-26)
fissure, fistula, and perianal abscess), and 79,808 patients were hospitalized with hemorrhoids. Patients with inflammatory anal lesions had a 3-fold increased risk of anal cancer that persisted over time. There was no persistent risk elevation in patients...
Molecular dynamics of protein-nucleic acid complexes
(2010-04-16)
for the spontaneously flipped base in the molecular dynamics simulation. The conclusion was that the adenosine at the R/G site is more flexible and that minor groove flipping is preferred over major groove flipping. In paper II, the ADAR2 deaminase domain was docked...
Hypoxia in arterial and venous specification during vascular development
(2009-08-14)
A developing embryo needs a constant supply of oxygen and nutrients in order to survive and grow into a functioning organism. During the earliest embryonic stages passive diffusion is enough to sustain the embryo. At later ...