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Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4...
Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells
(2010-01-15)
involved in arachidonic acid metabolism and the capacity to generate leukotriene (LT) B4 via the 5-lipoxygenase pathway in blood tumor cells from patients with precursor B-ALL (acute lymphoblastic leukemia) and AML (acute myeloid leukemia). In addition...
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
This thesis deals mainly with the synthesis of various sulfur/selenium-containing heterocyclic compounds, many of which include structural features present in several biologically active molecules, with particular emphasis ...
Transcriptional profiling of the kidney glomerulus
(2010-05-20)
The kidney glomerulus plays a crucial role in ultraltration of the blood through the glomerular capillary wall. Glomerulus injury may occur in many systemic and primary kidney diseases or as secondary eects to drugs and ...
On angiogenesis modulation
(2009-08-28)
the regulator of G-protein coupled signaling RGS5 was identified as a novel marker for pericytes; ii) how the role of Notch signaling in angiogenesis was characterized, and shown to regulate the number of endothelial tip cells, in turn affecting the density...
Isoforms of mammalian glutaredoxin 2
(2009-05-05)
Iron-sulfur proteins are characterized by the presence of iron-sulfur clusters containing sulfide linked iron centers in variable oxidation states. Glutaredoxins (Grx) are, among other redoxins, increasingly recognized to ...
Epidemiology and care of epilepsy in Vietnam
(2010-05-12)
of active epilepsy were thus identified. Age-adjusted incidence was 44.8/100,000 (95%CI 30.6-59.0), higher in those under 16 years, among people with lower education, and with lower income. Age-adjusted prevalence was 4.4 per 1,000 (95%CI 3.8-5.0), higher...
Structural enzymology of dormancy related proteins from Mycobacterium tuberculosis
(2009-01-09)
Mycobacterium tuberculosis, the causative agent of tuberculosis, is one of the most lethal infectious agents affecting humans. The World Health Organisation estimates that about one-third of the world s population is ...
Anxiety and depression in adolescent females : autonomic regulation and differentiation
(2010-02-19)
The prevalence of anxiety and depression is on the increase in adolescent
girls, as estimated by self-assessed symptom reports. There is a need for
implementation of validated instruments to identify those in need ...
Calcium signaling : molecular mechanisms and cellular consequences
(2008-11-21)
Cells exploit calcium (Ca2+) signaling to transmit information. In a
multicellular organism, each cell must be able recognize, process, and
respond to information received from the surrounding environment. In this
thesis ...