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The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Teleost retina : a model to study neurogenesis and angiogenesis
(2009-03-09)
Teleost models, zebrafish and medaka have become popular models to study
various aspects of developmental biology and genetics. The rapid
embryonic development, transparent embryos and the availability of many
mutants ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
3 times higher compared to C-section indicating fetal peptide release. Neutrophils from cord blood after normal delivery contain 10 times more cytoplasmatic cathelicidin peptide compared to corresponding cells after C-section where a strict granular...
Experimental studies of N-methyl-D-aspartate receptor NR3 subunits
(2008-04-25)
This thesis focuses on the NR3A and NR3B subunits of the excitatory
glutamate receptor N-methyl-D-aspartate (NMDA). Functional NMDA receptors
are believed to be tetrameric complexes with combinations of NR1 and NR2
subunits, ...
Structural and genetic characterization of lipopolysaccharides extracted from disease causing non-typeable Haemophilus influenzae strains
(2010-01-01)
, 2019lpt3 and 2019pgmB add to the previously published structure of 2019. In 1992 it was established that lactose is linked to the proximal heptose (Hep I) of the conserved triheptosyl inner-core moiety, no other structures were reported. We show...
Epidemiological and recovery facilitating studies of an urban population of stroke patients in Iran
(2010-05-28)
Introduction: Approximately 15 million people have a stroke annually in the world, of whom one third will die within one year and one third will suffer permanent disability. Over 85% of these deaths happen in people living ...
On the fate of triclosan in humans
(2009-05-22)
Triclosan is a chlorinated organic compound which, due to its antibacterial properties in vitro, has found widespread use in a variety of products such as textiles, plastics and healthcare products. Humans are directly and ...
Calcium signaling : molecular mechanisms and cellular consequences
(2008-11-21)
Cells exploit calcium (Ca2+) signaling to transmit information. In a
multicellular organism, each cell must be able recognize, process, and
respond to information received from the surrounding environment. In this
thesis ...
From stem cell to neuron : a Sox perspective
(2010-04-30)
, in neural progenitors, Sox3 "takes over" and binds to activated neural genes, but also to silent genes destined to become active in maturing postmitotic neurons. Finally, in postmitotic neurons these genes are bound by Sox11. The binding of Sox3 to silent...
New apheresis techniques in transplantation
(2008-11-21)
compatible living donor kidney recipients. Mean follow-up was 3 years and the study showed that clinical outcome is similar after ABO incompatible kidney transplantation with this protocol compared with ABO compatible kidney transplantation, both short...