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Biomarkers of suicide risk in psychosis
(2009-11-27)
Suicide and attempted suicide are major health problems. Approximately 1400 people die from suicide every year in Sweden and ten times more attempt suicide. Patients with schizophrenia spectrum psychosis have an increased ...
Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
between Env immunogens and CD4-expressing cells would negatively affect the elicitation of Envspecific immune responses, CD4 binding-competent and CD4 binding-defective trimers were constructed and inoculated into non-human primates. No difference...
Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells
(2010-01-15)
involved in arachidonic acid metabolism and the capacity to generate leukotriene (LT) B4 via the 5-lipoxygenase pathway in blood tumor cells from patients with precursor B-ALL (acute lymphoblastic leukemia) and AML (acute myeloid leukemia). In addition...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Chest wall sarcomas
(2010-03-05)
Aim: To evaluate initial symptoms and clinical features, diagnosis and delay
in osteosarcoma (OS), Ewing sarcoma (EWS) and chest wall chondrosarcoma
(CS). To assess treatment and identify prognostic factors in chest ...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around ...
Applications of nanotechnology in neuroscience : functionalized superparamagnetic nanoparticles as contrast enhancers in experimental magnetic resonance imaging
(2010-04-08)
Magnetic resonance imaging (MRI) is a noninvasive imaging technique that
helps clinicians not only to diagnose but also to plan the treatment of
invasive surgery and actually treat medical conditions. Superparamagnetic
iron ...