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Molecular studies of Hutchinson-Gilford progeria syndrome
(2009-05-22)
Hutchinson-Gilford progeria syndrome (HGPS) is a very rare genetic disease, with an incidence of 1 in 4-8 million live births, that causes segmental premature aging in children. The children look normal at birth but begin to develop symptoms...
The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells
(2008-09-04)
The tumor suppressor p53 is a critical regulator of life and death in
cells. The p53 protein is present at very low levels in cells under
normal conditions but accumulates in response to different stress
stimuli, such ...
Morbidity and mortality after bariatric surgery in Sweden
(2009-10-02)
Overweight and obesity has increased in Sweden and in the rest of the world during the last decades, probably due to a more sedentary lifestyle and changes in diets. Body mass index (BMI) is a commonly used index of ...
LXR and aromatase knock-out mice : animal models providing insight into human diseases
(2009-01-01)
In our characterization of mouse strains carrying mutations in nuclear
receptor and aromatase genes we have found phenotypes which resemble four
human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome
(SS), ...
Genetics of primary immunodeficiency diseases
(2009-10-15)
in the development of the disease and the frequency of several extended major histocompatibility complex haplotypes (including HLA B8, DR3; DR1, DQ5; DR7, DQ2) have previously been shown to be increased in Caucasian patients with IgAD. Based on our study, there is a...
Exploring a national practice-based register for the management of rheumatoid arthritis
(2008-10-17)
Rheumatoid arthritis (RA) is a chronic, inflammatory, auto-immune disease with an unpredictable and debilitating course. From diagnosis and onward, RA patients who need treatment with anti-rheumatic drugs will require ...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around ...
Gut microflora associated characteristics in children with celiac disease
(2009-05-08)
Aim: The over-arching aim of this thesis was to study some metabolic functions of the gut microflora in children with known or screening detected celiac disease (CD) and their first-degree relatives.
Materials: Study ...
Brain volume reduction over four decades in multiple sclerosis
(2010-05-07)
Introduction: Multiple sclerosis (MS) is a common neurological disease causing intermittent or cumulative disability, predominantly among women of child-bearing age. MS is a chronic inflammatory disease of the central ...
Factors associated with lung function impairment in children and adults with obstructive lung disease
(2008-05-14)
function at age 4 and 8 years in a birth cohort of 4,000 children and found that asthma symptom onset in the first 4 years of life was, on a group level, associated with impaired exhaled flows. This was found irrespective of the persistence of symptoms...