Search
Now showing items 1-10 of 319
Spread and distribution of drug resistance and compensatory mutations in Plasmodium falciparum
(2012-05-08)
resistance associated pvdhfr 57L+58R alleles were found in 2/57 samples. When analysing the worldwide collection of samples, the pfvp2 405V, 582K and 711P haplotype was associated with the for CQ resistance essential allele, pfcrt 76T (P=0.007). Samples...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
′-dithiobisindoles is described. In addition, the heterocyclic core of the marine alkaloid echinosulfone A, namely 3,3′-bis(indolyl) sulfone, was obtained by treatment of a 3-lithioindole derivative with bis(phenylsulfonyl) sulfide. These methodologies offer...
Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe
(2009-08-07)
response. We map genome-wide Gcn5 occupancy and show that Gcn5 is predominantly localized to coding regions of highly transcribed genes. We also map H3K14 acetylation during salt stress and show that Gcn5 collaborates antagonistically with the class...
Calcium signaling : molecular mechanisms and cellular consequences
(2008-11-21)
Cells exploit calcium (Ca2+) signaling to transmit information. In a
multicellular organism, each cell must be able recognize, process, and
respond to information received from the surrounding environment. In this
thesis ...
Cancer vaccine strategies and studies of human thioredoxin reductase splice variants
(2010-05-28)
genomic structure, leading to numerous splice variants. Peculiarly, the v3 splice variant encompasses a unique glutaredoxin domain, transcription of which is guided by an alternative promoter, which is located upstream of the TrxR1 core promoter...
Looking for arthritis regulating genes on mouse chromosome 6 & 14
(2008-11-05)
Rheumatoid arthritis (RA) is a chronic autoimmune disease of the joints with a complex aetiology affected by largely unknown genetic and environmental factors. Since ~60% of susceptibility to RA is genetically inherited, ...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
at silent regions and in repression and activation of gene expression. We proposed that independent of gene length, a typical fission yeast gene shows a 5 to 3 polarity, i.e., the histone acetylation levels peak near the ATG and gradually decrease...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Hearing in menopausal women and in women with Turner syndrome : a model for hearing matured in an estrogen-deficient environment
(2009-04-03)
Epidemiological studies have shown that women have better high-frequency
hearing than men in virtually all age groups, regardless of
noise-exposure, and that agerelated hearing decline starts after age 30
in men but not ...