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Effects of an expanded rehabilitation programme in patients with ischemic heart disease
(2009-11-12)
. The primary composite endpoint was time to first cardiac event defined as CV death, MI or readmission due to CV disease. There was a significant reduction in the primary composite endpoint among those in the ECR as compared to UC group (47.7% vs. 60.2%; hazard...
Dermal exposure determinants : a pesticide exposure assessment approach for developing countries
(2008-11-26)
Background: We know little about the levels of exposure to pesticide in
subsistence farmers mainly because of lack of easy to use and low cost
pesticide exposure assessment methods.
Aim: This thesis aimed to develop ...
On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate
(2008-05-15)
Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Synthesis of estradiol mimetics and potential anti-Alzheimer’s agents
(2010-11-08)
This thesis is composed of two projects, both involving synthesis aimed at drug discovery.
The first project covers method development for the synthesis of substances that can be used in estrogen replacement therapy. ...
Exploring a national practice-based register for the management of rheumatoid arthritis
(2008-10-17)
Rheumatoid arthritis (RA) is a chronic, inflammatory, auto-immune disease with an unpredictable and debilitating course. From diagnosis and onward, RA patients who need treatment with anti-rheumatic drugs will require ...
Proximal femoral fractures : functional outcome, quality of life and mortality
(2008-11-27)
A hip fracture in the elderly is one of the most devastating consequences
of osteoporosis and has a high rate of complications, including death and
a serious threat to the patient s future mobility, social functioning,
quality ...
Genetic and immunological mechanisms regulating neuroinflammation
(2010-10-27)
Multiple sclerosis (MS) is the most common neurological disorder in young adults and imposes both health and socioeconomic burdens on society. The cause and aetiology of MS are incompletely understood and current treatments ...
Hypospadias : gene mapping and candidate gene studied
(2009-08-28)
and subsequent fine mapping gave a maximum linkage in both parametric (LOD score 2.71) and non-parametric (NPL score 5.01) single-point analyses for marker D7S640. A susceptibility haplotype shared by all affected boys was identified by markers D7S2519 and D7S...
Functional gastrointestinal disorders : co-morbidity and non-somatic aspects
(2008-05-19)
Aims of the thesis: The first aim, (Study I) of this thesis was to
compare co-morbidity of the reported symptoms and its relation to
healthcare seeking behaviour among non-patients who had persistent
functional ...