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Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Cataract induced by UVR-B 300nm : characterization and genetic modulation of the lens sensitivity to oxidative stress
(2008-03-28)
Cataract is defined as an opacification of the lens resulting in visual
impairment. Worldwide, it is the number one cause of blindness and there
are currently no strategies to prevent the onset of the disease. Cataract
surgery ...
Induction and repair of DNA double-strand breaks in human cells exposed to different radiation qualities
(2008-02-22)
V/nm. Exposure of human cells to high-LET radiation resulted in clustering of DSB, leading to an excess of small DNA fragments (< 1 Mbp), as measured by pulsed-field gel electrophoresis (PFGE). Importantly, it was found that DNA organization into chromatin fibers...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Functional genomics studies of PINK1
(2007-10-25)
established a human in vivo model for mitochondrial dysfunction. Microarray analyses of the same sample-set suggested that PINK1, a novel mitochondrial kinase, was down regulated during inactivity. PINK1 is transcribed from a complex locus, alternatively...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...
Proinflammatory factor mediated lymphocyte activation-the pivotal role of leukotriene B4
(2007-11-06)
. BLT1, the high-affinity receptor of LTB4 was expressed on T
cells in the infected cultures. Moreover, we found that LTB4 added to
infected cultures, which did not receive the PSK and Trx80, induced
functional activation of the T cells. LTB4 activated...
Analysis of kidney glomerular and microvascular transcriptomes
(2007-09-21)
Kidney glomeruli play a crucial role in the maintenance of body homeostasis. Many diseases attack the kidney function by primarily affecting glomeruli. However, the transcriptome profiles and the function of the glomerulus ...
Role of transcription factors in sensory neuron specification
(2007-02-09)
the transcription factor Foxs1 as an early sensory neuronal marker and use it to describe molecularly distinct waves of neurogenesis in the trunk DRG. Our work shows that Runx1 directs the establishment of the TrkA+ nociceptive subclass of neurons. We describe...
Renal insufficiency, mortality and myocardial infarction
(2008-05-09)
for the highest versus the lowest quartile of the apoB/apoA-1 ratio was 2.88 (2.54 to 3.26) compared to HR, 3.35 (2.25 to 4.91) for those with CKD. After adjustment for the total cholesterol/ high-density lipoprotein cholesterol ratio, an increase by one standard...