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Molecular epidemiology of pneumococcal carriage and invasive disease
(2007-02-02)
Streptococcus pneumoniae, also known as pneumococcus, is a major
contributor to morbidity and mortality worldwide. It is the main cause of
respiratory tract infections such as otitis media and sinusitis, but also
causes ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
Gliomas are the most common glial neoplasms, accounting for nearly 70% of
all primary brain tumours. The progression of low-grade gliomas into more
aggressive tumours is supported by the abnormal function of several
prot ...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Observing the darkest matter of the genome : expression of human endogenous retrovirus W elements
(2008-05-09)
The human genome is composed of coding genes and vast stretches of
sequences largely considered junk. Researchers are, however, uncovering
widespread and extensive transcription of not only the coding, but also
of the ...
Exposure to skin irritants : validation of questions and epidemiological aspects
(2008-03-14)
Hand eczema is common, and is the most frequent occupational skin disease. Exposure to skin irritants contributes to hand eczema. Common skin irritants are water, detergents, chemicals and foodstuffs. The aim of this thesis ...
Esophageal cancer surgery : factors influencing survival
(2007-01-19)
The principal aim of this thesis was to address factors that may affect
survival after esophageal cancer surgery. Surgical resection remains the
only established potentially curative treatment for patients with
resectable ...
Bisphosphonate treatment of children and adolescents with osteogenesis imperfecta : effects on clinical symptoms and bone turnover
(2007-10-25)
protocol every six month for 1-2 years then annually. In Study I three adolescents with severe OI were treated during 2-5 years. In Study II we treated 28 children aged 0.6-18 years during 2-9 years. They had severe or milder forms of OI with vertebral...
Factors associated with brain tumor risk : with focus on female sex hormones and allergic conditions
(2008-09-03)
Every year approximately 1200 people in Sweden are diagnosed with a brain
tumor. The two main histological types of brain tumors, gliomas and
meningiomas, differ in terms of their localization, histology, prognosis,
and ...
Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects
(2008-04-04)
Oxaliplatin is a platinum-based cytostatic drug. It is used in
combination with 5-fluorouracil and leucovorin for palliative and
adjuvant treatment of metastatic colorectal cancer. The biotransformation
of oxaliplatin ...