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Bisphosphonate treatment of children and adolescents with osteogenesis imperfecta : effects on clinical symptoms and bone turnover
(2007-10-25)
Background: Osteogenesis imperfecta (OI) is a group of genetic diseases with a wide spectrum of severity, ranging from very mild bone fragility to lethal forms. Without treatment the more severe forms have multiple fractures ...
Nerve-induced release of nitric oxide in gastrointestinal and erectile tissue
(2004-10-29)
Nitric oxide (NO) is an important messenger of the autonomic nervous system, innervating the gastrointestinal and urogenital tracts among many other tissues. The aim of the present thesis was to study the nitrergic ...
Biosynthesis and biological role of leukotrienes in B lymphocytes
(2006-11-27)
Leukotrienes (LT) are potent lipid mediators, synthesized from arachidonic acid (AA) upon cell activation. The essential enzyme for leukotriene biosynthesis is 5-lipoxygenase (5-LO), converting AA, through a two step process ...