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Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
β-alanine synthase : one reaction, two folds and mechanisms
(2008-01-11)
beta-alanine synthase (betaAS) is the third enzyme in the reductive
pyrimidine catabolic pathway which is responsible for the breakdown of
pyrimidine bases, including several anti-cancer drugs in higher
organisms. We ...
Corticosteroids in advanced cancer : epidemiology, symptom relief and patient experiences
(2007-04-06)
Cortisol is the principal circulating glucocorticoid in man and has a
wide variety of effects in the body. In advanced metastatic cancer,
glucocorticoids are used to alleviate symptoms such as anorexia, poor
strength ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Molecular imaging of the serotonin system in human behaviour
(2007-02-16)
The serotonin (5-HT) neurotransmission system has a role in essential
physiological and psychological functions such as sleep, eating
behaviour, sexuality, perception, emotion and cognition. Individual
measures of serotonin ...
Novel treatment strategies and regulation of IgE-mediated allergic disease
(2008-02-15)
Allergic symptoms such as rhinoconjunctivitis, asthma or gastrointestinal
symptoms, triggered by inhaled or ingested allergens cross-linking
allergen-specific IgE on mast cells or basophils, are defined as
IgE-mediated ...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Analysis of different forms of locomotor behavior in lamprey
(2007-05-25)
The ability to locomote, that is move actively in space, is characteristic of the animal kingdom. Many species are capable of different forms of locomotion. They include forward and backward locomotion, fast and slow ...
Socioeconomic consequences of obesity : population-based longitudinal studies of Swedish men
(2008-03-28)
The overall aim of the thesis was to study if Swedish obese male
adolescents become socioeconomicly disadvantaged in later life. Among
Swedish men born 1951-79, who went through military conscription
examination at age ...
Factors associated with brain tumor risk : with focus on female sex hormones and allergic conditions
(2008-09-03)
Every year approximately 1200 people in Sweden are diagnosed with a brain
tumor. The two main histological types of brain tumors, gliomas and
meningiomas, differ in terms of their localization, histology, prognosis,
and ...