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The meaning of health and sexuality as experienced by Tanzanian men and women living with HIV/AIDS
(2007-05-22)
Background: Sub-Saharan Africa has for more than two decades been hit by the human immunodeficiency virus/acquired immune-deficiency syndrome, HIV/AIDS pandemic. In Tanzania, the prevalence of HIV is estimated to 7 percent and about 1.8,million...
Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Identification of the susceptibility genes in type 1 diabetes and diabetic nephropathy
(2007-11-02)
Genetic susceptibility plays an important role in the pathogenesis of
type 1 diabetes (T1D) and diabetic nephropathy (DN). The present study
aims to investigate the association between single nucleotide
polymorphisms ...
Role of inflammatory and mitochondria genes in adipose tissue and obesity
(2007-09-28)
significantly upregulated in obesity and this led us to investigate the secretion of the corresponding proteins. We found that monocyte chemoattractant protein 1 (MCP1) was the only upregulated chemokine on gene level to be secreted from both adipose tissue...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various...
Aspects of immune activation in HIV-1 infection
(2007-05-25)
Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Joint destruction in rheumatoid arthritis : experimental, clinical and epidemiological studies
(2007-11-23)
Background: Rheumatoid arthritis (RA) is a common autoimmune disease
characterized by chronic polyarticular synovial inflammation. Erosive
joint destruction represents a major unsolved complication of RA.
Objectives: ...
Renal insufficiency, mortality and myocardial infarction
(2008-05-09)
for the highest versus the lowest quartile of the apoB/apoA-1 ratio was 2.88 (2.54 to 3.26) compared to HR, 3.35 (2.25 to 4.91) for those with CKD. After adjustment for the total cholesterol/ high-density lipoprotein cholesterol ratio, an increase by one standard...