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Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
RNA molecules have several important functions in a cell. They carry the genetic information from DNA to protein, act as catalysts and regulate gene expression. Both DNA and RNA consist of nucleotides, DNA molecules are ...
Aspects of immune activation in HIV-1 infection
(2007-05-25)
Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under...
Regulation of insulin-like growth factor-1 receptor expression and signaling
(2007-05-25)
Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin
receptor tyrosine kinase family is a broadly expressed transmembrane
receptor that plays a key role in malignant cell growth. IGF-1R transmits
information provided...
Functional and diagnostic aspects on adrenocortical adenoma
(2007-04-13)
expression of the steroid synthesizing enzymes and thereby identify the steroid production of adrenocortical adenoma. In vitro release of aldosterone and cortisol from thin slices was compared to the mRNA expression of CYP11B2, CYP11B1 and CYP17, which...
Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications
(2007-08-17)
Uveal melanoma is the most common primary intraocular malignant tumor in
adults with 30% to 50% of patients that ultimately succumb to metastatic
disease, mainly to the liver. Although new diagnostic and therapeutic
tools ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
On the role of HMGB1 and resistin in severe sepsis and septic shock
(2007-12-21)
profiles, and remained elevated up to one week, long after other studied cytokines had returned to low values. For resistin, but not for HMGB1, we could also show significant correlations to disease severity as measured by SOFA and APACHE II scores...
Molecular imaging of the serotonin system in human behaviour
(2007-02-16)
control subjects were examined with PET and [11C]WAY100635,
a radioligand that is selective for the serotonin 5-HT1A receptor.
Personality traits were assessed with the Temperament and Character
Inventory (TCI) self-report questionnaire. Availability of 5...