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Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Aspects of immune activation in HIV-1 infection
(2007-05-25)
Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications
(2007-08-17)
Uveal melanoma is the most common primary intraocular malignant tumor in
adults with 30% to 50% of patients that ultimately succumb to metastatic
disease, mainly to the liver. Although new diagnostic and therapeutic
tools ...
Role of inflammatory and mitochondria genes in adipose tissue and obesity
(2007-09-28)
significantly upregulated in obesity and this led us to investigate the secretion of the corresponding proteins. We found that monocyte chemoattractant protein 1 (MCP1) was the only upregulated chemokine on gene level to be secreted from both adipose tissue...
Renal insufficiency, mortality and myocardial infarction
(2008-05-09)
for the highest versus the lowest quartile of the apoB/apoA-1 ratio was 2.88 (2.54 to 3.26) compared to HR, 3.35 (2.25 to 4.91) for those with CKD. After adjustment for the total cholesterol/ high-density lipoprotein cholesterol ratio, an increase by one standard...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Molecular imaging of the serotonin system in human behaviour
(2007-02-16)
control subjects were examined with PET and [11C]WAY100635,
a radioligand that is selective for the serotonin 5-HT1A receptor.
Personality traits were assessed with the Temperament and Character
Inventory (TCI) self-report questionnaire. Availability of 5...
Low back pain among industrial workers : occupational health studies on prevalence, incidence, and associations with work and lifestyle in I.R. Iran
(2007-02-23)
This thesis presents the results from a prospective industrial population
cohort study on epidemiology and risk factors for low back pain (LBP) in
Iran. The four papers in the thesis were based on a cross-sectional
survey ...