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From stem cells to neurons : a BMPy ride
(2007-10-05)
neural specification, BMP4 promotes astrocytic while inhibiting oligodendrocytic cell fates, an activity by BMP4 also seen in NSCs. Furthermore, the differentiation downstream of BMP4 in NSCs is dependent on the cell density, inducing mesenchymal...
Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(2007-10-26)
to become ex-posed to ethanol following ingestion. In this thesis I explored their reactions to ethanol and EtP in the setting of an acute inflammatory reaction, e.g. after challenge with LPS, IL-1, TNFalpha or LTB4 mimicking, for instance, sepsis...
Bisphosphonate treatment of children and adolescents with osteogenesis imperfecta : effects on clinical symptoms and bone turnover
(2007-10-25)
compression fractures. In Study III eleven infants aged 3-13 months were treated during 3-6 years and were at the latest recording at median age of 4.8 years compared to our own historic control group of untreated age and type-matched children with OI...
Evaluation of reverse transcriptase assay for viral load monitoring
(2007-05-17)
Retaining an active reverse transcriptase (RT) enzyme is a fundamental requirement for all retroviruses to replicate. Bearing in mind that HIV has a very high propensity to mutate measuring RT activity to determine the ...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...
Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria
(2007-02-09)
Artemisinin (ART) class of compounds are of special interest due to their
rapid onset of action and high activity against multidrug resistant
malaria. The major drawback in monotherapy with ART and its derivatives
is ...
Proinflammatory factor mediated lymphocyte activation-the pivotal role of leukotriene B4
(2007-11-06)
-gamma
to the NK cell depleted cultures.
Further we demonstrated that leukotriene B4 (LTB4) was involved in the
effect of the PSK and Trx80. LTB4 was detected in the medium, and T cell
activation was compromised by addition of leukotriene biosynthesis
inhibitors...
Joint destruction in rheumatoid arthritis : experimental, clinical and epidemiological studies
(2007-11-23)
Background: Rheumatoid arthritis (RA) is a common autoimmune disease
characterized by chronic polyarticular synovial inflammation. Erosive
joint destruction represents a major unsolved complication of RA.
Objectives: ...
Preservation of male fertility in childhood acute leukemia : an experimental study addressing novel strategies and putative risks
(2007-10-05)
on surface markers, the flow cytometric sorting (FACS) and immunomagnetic cell sorting (MACS), were evaluated. First CD4/MHC-Cl I and Ep-CAM, were identified as appropriate markers for leukemic and germ cells, respectively Labeling these cells...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...