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Differences i tropism and viral assembly pathways of human herpesvirus 6A and 6B (HHV-6A and 6B) and association of host cell proteins in HHV-6A virions
(2007-05-24)
Human herpesvirus 6A and 6B (HHV-6A and 6B) are considered to be T-lymphotropic viruses. The overall nucleotide sequence identity between the two variants is 90% and each differs by only nine variant-specific open reading frames. HHV-6A and 6B have...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
.0-1.7). Mineral oil exposure was associated with a particularly high risk of developing rheumatoid factor positive RA (RR =1.4, 95% CI =1.0-2.0) and anti-citrulline positive RA (anti-CCP+RA) (RR =1.6, 95% CI=1.1-2.2). The highest risk of developing anti- CCP...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. ...
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
Nuclear receptors are a family of transcription factors involved in many
biological processes. They represent key potentials as therapeutic
targets for several clinical conditions such as diabetes, obesity,
cardiovascular ...
Repressing the hedgehog signalling pathway
(2007-11-28)
The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation of the pathway is found in tumours. Mutations in Hh pathway components are found in several tumour types, including basal ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
B-cell survival factors in multiple sclerosis and myasthenia gravis
(2007-03-14)
Multiple sclerosis (MS) is a chronic, progressive neurological disease in which death of myelin-producing oligodendrocytes and axonal damage are prominent pathological features. The cause of MS is unknown but genetic and ...
The N-methyl-D-aspartate receptor subunit NR3A : cloning, expression and interacting proteins
(2008-03-28)
This thesis focuses on the subunit NR3A, which together with subunits NR1, NR2A-NR2D and NR3B builds the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). The receptor is most likely a tetramer, containing at least ...
Analysis of different forms of locomotor behavior in lamprey
(2007-05-25)
The ability to locomote, that is move actively in space, is characteristic of the animal kingdom. Many species are capable of different forms of locomotion. They include forward and backward locomotion, fast and slow ...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...