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The N-methyl-D-aspartate receptor subunit NR3A : cloning, expression and interacting proteins
(2008-03-28)
This thesis focuses on the subunit NR3A, which together with subunits NR1, NR2A-NR2D and NR3B builds the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). The receptor is most likely a tetramer, containing at least ...
Regulation of mitochondrial gene expression in metazoa
(2013-08-12)
Mitochondria are essential organelles of eukaryotic cells and their main function is to provide the cell with the ubiquitously used energy currency ATP. Impaired energy conversion caused by mitochondrial dysfunction is a ...
Molecular mechanisms of growth suppression by pharmacologically activated p53
(2009-05-14)
The tumor suppressor p53 is a transcription factor that is crucial for protecting cells from cancer development. The importance of p53 tumor suppression function is highlighted by the fact that the p53 pathway is inactivated ...
Long-term follow-up in children born with congenital diaphragmatic hernia
(2018-03-28)
Congenital diaphragmatic hernia (CDH) is a developmental defect which occurs in approximately 1 per 3000 births. The incomplete development of the diaphragm early in gestation allows abdominal viscera to herniate into the ...