Search
Now showing items 1-10 of 348
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
-modulated factor 1 (PMF-1) and germinal center associated
nuclear protein (GANP) in glucocorticoid signalling.
RIP140 represses ligand activated nuclear receptors, such as GR and LXR.
It is localized in small nuclear foci targeted by a 40 amino acid long
sequence...
Combined oral contraceptives : impact on the vulvar vestibular mucosa and pain mechanisms
(2007-08-24)
Objective: The main aim of this thesis was to study the impact of
combined oral contraceptives (COC) on the vulvar vestibular mucosa and
pain mechanisms; in healthy women and in women with provoked
vestibulodynia (former ...
Method specific factors in personality tests
(2007-09-21)
Two of the most widely used personality assessment methods are the
Rorschach (Exner, 1993) and the MMPI/MMPI-2 (Hathaway & McKinley, 1943;
1989). Both methods have demonstrated validity for particular purposes
(Meyer & ...
Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
by immature rats Leydig cells., (ii) possible antiapoptotic effects of IGF-I during testicular development and the role played by IGF-1R in this context; (iii) the influence of IGFBP-3 on apoptosis and steroidogenesis in rat Leydig cells in relation...
Identification of the susceptibility genes in type 1 diabetes and diabetic nephropathy
(2007-11-02)
Genetic susceptibility plays an important role in the pathogenesis of
type 1 diabetes (T1D) and diabetic nephropathy (DN). The present study
aims to investigate the association between single nucleotide
polymorphisms ...
Functional genomics studies of PINK1
(2007-10-25)
established a human in vivo model for mitochondrial dysfunction. Microarray analyses of the same sample-set suggested that PINK1, a novel mitochondrial kinase, was down regulated during inactivity. PINK1 is transcribed from a complex locus, alternatively...
Aspects of immune activation in HIV-1 infection
(2007-05-25)
Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...