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Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
by immature rats Leydig cells., (ii) possible antiapoptotic effects of IGF-I during testicular development and the role played by IGF-1R in this context; (iii) the influence of IGFBP-3 on apoptosis and steroidogenesis in rat Leydig cells in relation...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Aspects of immune activation in HIV-1 infection
(2007-05-25)
Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...