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The hepatitis C virus and immune escape : relation between sequence variations and the in vitro and in vivo functionality of the non-structural 3/4A complex
(2006-11-24)
and 3 strains. Fine mapping of the 1073-1081 epitope of gt 1 revealed that positions 2, 3, 5, 7 and 9 were essential for immune recognition. Mutations at these positions would therefore mediate immune escape, however, almost no mutations were identified...
Esophageal cancer surgery : factors influencing survival
(2007-01-19)
The principal aim of this thesis was to address factors that may affect
survival after esophageal cancer surgery. Surgical resection remains the
only established potentially curative treatment for patients with
resectable ...
Cardiorespiratory fitness and cardiovascular disease risk factors in children and adolescents
(2007-03-09)
Cardiovascular disease (CVD) events occur most frequently during or after the fifth decade of life, however, there is evidence indicating that the precursors of CVD has its origin already in the first or second decade of ...
Cardiorespiratory fitness and cardiovascular disease risk factors in children and adolescents
(2007-03-09)
Cardiovascular disease (CVD) events occur most frequently during or after the fifth decade of life, however, there is evidence indicating that the precursors of CVD has its origin already in the first or second decade of ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
Host-pathogen interactions in severe group A streptococcal infections
(2007-12-28)
Streptococcus pyogenes, also called group A Streptococcus (GAS), is an important human pathogen ranked number 9 on the list of global killer pathogens. It causes a wide spectrum of disease, including uncomplicated superficial ...
Genetic studies of colorectal cancer
(2007-02-02)
q22.32-31.1 with a multipoint LOD score of 2.4. Haplotype analysis defined the region to 7.9 cM between the markers D9S280 and D9S277. Hence, these data supports the evidence of a susceptibility locus predisposing to adenoma and colorectal cancer...
Caesarean section on maternal request : personality, fear of childbirth and signs of depression among first-time mothers
(2007-05-15)
Aim: The overall aim of this thesis was to study healthy first-time mothers
requesting and undergoing an elective caesarean section (CS) and to
compare these to healthy first-time mothers planning a vaginal delivery.
The ...
Analysis of kidney glomerular and microvascular transcriptomes
(2007-09-21)
Kidney glomeruli play a crucial role in the maintenance of body homeostasis. Many diseases attack the kidney function by primarily affecting glomeruli. However, the transcriptome profiles and the function of the glomerulus ...
Mild traumatic brain injury : clinical course and prognostic factors for postconcussional disorder
(2006-12-29)
Background: Mild traumatic brain injury (MTBI) is frequent and sometimes leads to
persistent disability. It remains a matter of controversy as to what
impact the different main determinants - brain injury factors ...