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Colon cancer : disease related proteins in tumor tissue and serum
(2004-11-19)
Despite the progress in surgical techniques and adjuvant therapies the
mortality of around 60% within the group of colon cancer patients did not
decrease significantly over the last decades. This determines a growing
demand ...
Synovial sarcoma : molecular, biological and clinical implications
(2004-08-13)
Synovial sarcoma is a rare but mostly aggressive soft tissue tumor that mainly affects children and young adults. The tumor usually occurs in the vicinity of large joints, and may be subdivided into a classical biphasic ...
Genome instability, gene expression and prognosis in breast cancer
(2005-02-18)
Aneuploid cancers are regarded as being more malignant than tumors of other ploidy categories, and they are characterized by increased genomic instability. Our investigations resulted in the characterization of an aneuploid ...
Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia
(2006-08-25)
Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult ...
Prevention and treatment of hepatitis B virus infection
(2005-05-06)
surrogate marker for HBV DNA levels in HBeAg-negative carrier mothers. Of 179 sera analysed, eight (4.5%) tested positive for HBeAg, whereas 171 (95.5 %) were HBeAg-negative. Among the HBeAg-negative mothers, nine had H13V DNA levels predefined as high...
Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia
(2006-01-20)
-DC and compared it to the T-cell stimulatory capacity of DC that were fused with tumor cells. Following overnight incubation 22.6 ± 6.2% (mean ± SEM) of DC had endocytosed apoptotic leukemic cells while the frequency of DC-leukemic cell hybrids was 10.5 ± 2.6%. A...
Standardization and application of quantitative PCR methods in patients with hematological malignancies
(2004-10-29)
Using modem combination chemotherapy regimens, it has been possible to increase the rate of complete remission (CR) in acute lymphoblastic (ALL) and acute myeloid leukemia (AML). The major reason for treatment failure in ...
Immunotherapy with the anti-EpCAM monoclonal antibody and cytokines in patients with colorectal cancer : a clinical and experimental study
(2005-11-18)
The tumor-associated antigen EpCAM (epithelial cell-adhesion molecule) (C017-1A) is over expressed by various human carcinomas, including colorectal carcinoma (CRC). This antigen can be used as a target structure for ...
Identification, cloning and characterization of the p53 induced gene human Wig-1
(2004-11-26)
The tumor suppressor p53 is a transcription factor that responds to
various kinds of cellular stress. In respons to the sensed stress it is
able to induces cell cycle arrest and apoptosis. In order to achieve
these ...
Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes
(2004-11-12)
expression of the cationindependent mannose-6-phosphate receptor (CI-MPR), a receptor for granzyme B, and decreased CTL-lysis of IFN-treated uveal melanoma cells. In another study, we examined the regulatory role of IFN-gamma on the sensitivity of uveal...