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The ins and outs of notch ligands and downstream events
(2006-05-26)
Signaling through the Notch receptor constitutes an evolutionarily conserved pathway important for embryonic development of many organs, including the central nervous system and vasculature, in multicellular animals. The ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Apoptosis in chronic inflammation, with specific reference to airway disease
(2006-09-08)
Mechanisms governing the normal resolution processes of inflammation in the lung are poorly understood, yet their elucidation may lead to a greater understanding of the pathogenesis of several pulmonary inflammatory ...
Genetic and environmental factors in the development of externalizing symptoms from childhood to adolescence
(2005-11-11)
Externalizing problems, such as hyperactivity, impulsivity, aggression, violation of legal or social norms, and delinquent behavior, tend to persist from childhood to adolescence. There are also high levels of comorbidity ...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
is in strong linkage with -318C/T and is more frequently present in MG patients with thymoma. MG patients carrying -318C showed significantly decreased expression of CTLA-4 mRNA in non-stimulated cells. In the present study, the relationship of the expression...
Clinical and epidemiological aspects of pelvic floor dysfunction
(2004-10-08)
for identifying POP were constructed, and from these five questions were identified to in combination have a sensitivity of 92.5 % and a specificity of 94.5 % for POP. The final questionnaire was further tested and used in a cross-sectional study with 8000...
Inflammatory status in adolescents : the impact of health determinants such as overweight and fitness
(2006-03-07)
status. Studied parameters were: detailed anthropometry, fitness and for the evaluation of inflammatory status, serum acute phase proteins (C-reactive protein, ceruloplasmin and complement factors C3 and C4), as well as in vitro production of interleukin...
Hidden Markov models for remote protein homology detection
(2005-12-23)
genomes we predicted 120 sequences that lacked previous annotation as possible GPCRs. The majority of these predictions (102) were in C. elegans, but also 4 were found in human and 7 in mouse....
Long-term neurodevelopmental outcome after moderate neonatal encephalopathy and after post-term birth : two population-based studies
(2006-03-17)
Long-term neurodevelopmental outcome in two population-based groups of children with different perinatal events was studied: A) Children born at term with moderate neonatal encephalopathy (NE) and B) children born post-term ...
Modeling the economics of prevention
(2005-04-29)
Cardiovascular disease, particularly coronary heart disease and stroke, is the most common cause of death world wide, with a prevalence that is expected to increase. The consequences of the modern lifestyle such as obesity ...