Search
Now showing items 1-10 of 18
The ins and outs of notch ligands and downstream events
(2006-05-26)
Signaling through the Notch receptor constitutes an evolutionarily conserved pathway important for embryonic development of many organs, including the central nervous system and vasculature, in multicellular animals. The ...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation
(2006-08-25)
Immediately upon transcription, messenger RNA molecules become associated with proteins to form ribonucleoprotein (RNP) complexes, usually called mRNP particles. The mRNPs are the actual targets for regulation and dictate ...
Renal function decline and optimized planning for kidney replacement therapy
(2022-05-18)
Chronic Kidney disease (CKD) is an increasing health problem world-wide, and the prevalence increases with age. CKD is a life-threatening condition, with high risk of cardiovascular disease and mortality. Patients with ...
Factors influencing splanchnic microcirculation in animal models of endotoxaemia
(2011-04-20)
Even though severe sepsis and septic shock therapy has improved in recent years, mortality remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut permeability have long been presumed to ...
CADASIL : a pure model for studying cerebral small vessel disease
(2019-05-23)
Cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) is caused by a mutation on the NOTCH3 gene. The pathological driver behind this disease is the loss of vascular smooth ...
Child abuse : clinical investigation, management and nursing approach
(2010-12-01)
The overall aim of this thesis is to describe how children suspected of being abused were taken care of in a large children’s university hospital.
Study I. Aim: To evaluate clinical investigations for suspected child ...
Epidemiological studies of suicide in patients with psychiatric illness
(2010-10-28)
A link between suicide and psychiatric illness is well recognized. However, knowledge is limited as to what characterizes suicide in different mental disorders. The overall aim of the work described in this thesis was to ...
Vascular remodeling in pulmonary hypertension
(2015-05-22)
Pulmonary hypertension (PH) is a progressive obliterative vasculopathy with multifactorial etiology and high mortality rate. Endothelial dysfunction, excessive vascular remodeling, inflammation and in situ thrombosis ...
Prior knowledge and present events in the brain
(2005-08-05)
Our experience the world is dependent on both the surroundings and the brain. In other words, perception is a synthesis of incoming signals, internal state, and previous knowledge rather than a mere reflection of the ...