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Foregut motility disorders : a clinical and experimental study
(2004-08-13)
Objective: To investigate some clinical aspects and treatment modalities
of foregut motility disorders and to experimentally explore some
mechanisms involved. Special emphasis has been put on elucidating and
evaluating ...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
dysfunction in prion diseases. For this purpose I used an immortalized gonadotropin-releasing neuronal cell line (GT1-1) that is susceptible to a mouse-adapted scrapie strain. This cell line represents a suitable system for my studies since the cells possess...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
positive epicutaneous patch test reactions, at 72h, an increased number of GAP43 immunoreactive nerve fibres were found in the eczematous compared to control skin. Semiquantification showed an increase in dermal substance P and its neurokinin 1 receptor...
Studies on neuroimmune interactions in allergic inflammation with focus on neurotrophins
(2006-09-29)
and Th1/Th2 cytokine ratio was observed in allergic subjects only. Furthermore, PBMC from asthmatic subjects released more BDNF than PBMC from healthy controls. In response to stress, the release of BDNF from PBMC increased in healthy controls...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
disease was 5.1-fold and 3.8-fold increased in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was about 8-fold elevated in water pipe smokers and 5-fold elevated...
Cytokines in the nervous system with emphasis on interleukin-1 receptor-mediated activity
(2005-03-11)
Interleukin-1 (IL-1) is one of the most important pro-inflammatory cytokines and plays a pivotal role in the neuroinflammation associated with certain forms of neurodegeneration, such as epilepsy, cerebral ischemia, trauma, and Alzheimer's disease...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
factors. In scrum most IGF circulate in a ternary complex with IGF-binding protein-3 (IGFBP-3) and the acid labile subunit (ALS). The affinity between IGF and IGFBP-3 exceeds that between IGF and the type 1 IGF receptor demonstrating that most...
Hormonal and paracrine influences on Leydig cell steroidogenesis
(2006-08-18)
evoked by two stimulators of steroidogenesis, hCG and the pro-inflammatory cytokine IL-1α were investigated. Both hCG and IL-1α activated the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in primary cultures of immature rat Leydig cells...
Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma
(2006-10-27)
PDTC was use to confirm the role of NFκB in the cochlea. Pretreatment of PDTC caused an elevation of auditory thresholds and lowered nuclear translocation of NFκB in the SGNs. Steroid receptor co activator 1 (SRC-1), a GR co-regulatory protein also...
The Minnesota model treatment for substance dependence : program evaluation in a Swedish setting
(2006-11-10)
between the baseline assessment and 1-year follow-up, while no change was found in the employment and medical areas. Those who experienced problem drinking reported significantly more employment, family and psychiatric problems than non-problem drinkers...