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Expression of cathelicidin antimicrobial peptides in man and rat
(2004-11-26)
Endogenous antimicrobial peptides are effectors of innate immunity. They kill microorganisms by disrupting their cell membranes, but are also believed to have signaling functions in the immune system. They are present in ...
Synthesis and evaluation of new PET radioloigands for imaging central norepinephrine transporters
(2006-04-28)
The noradrenergic (NE), serotonergic (5-HT) and dopaminergic (DA) neurotransmission systems all have specific proteins responsible for the regulation of synaptic concentrations of neurotransmitter in the central nervous ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
from the first study was used, but underestimated the ribavirin dose. After dose adjustments a mean dose was 2540 mg/day. Due to anaemia, 2 patients required blood transfusions, twice. 9 patients completed treatment and 9 patients were cured...
Effects of gonadal hormone deficiency on bone mineral density : can physical activity increase bone mineral density in women?
(2006-08-11)
Osteoporosis with its associated fragility fractures is a global health care problem. The incidence of ftagility ftactures has increased dramatically the last 50 years. This has been suggested to at least in part be due ...
Anxiety, exhaustion and depression in relation to periodontal diseases
(2006-03-10)
level in GCF was increased, whereas the patients in Study IV surprisingly showed lower cortisol values in GCF than the controls. The level of cortisol in saliva was similar in both groups. Neither did the levels of matrix metalloproteinases-8, -9 (MMP-8...
Prevention of complications in pediatric cataract surgery
(2004-11-26)
This thesis was performed to find ways to lessen the complications to pediatric cataract surgery, which is an increasingly safe procedure, also in infants. However, there are some complications to the surgery, which threatens ...
Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma
(2006-10-27)
The hypothalamic pituitary adrenal axis (HPA axis) regulates nearly all neuroendocrine responses of the body. An active HPA axis is crucial to maintaining homeostasis. An altered reactivity of the HPA axis can affect several ...
Nitric oxide and evaluation of different treatments in experimental colitis and inflammatory bowel disease
(2006-11-10)
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic inflammatory disorder of unknown etiology of the gastrointestinal tract. Central features of IBD are increased ...
Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9
(2005-09-09)
as in yeast microsomes with recombinantly expressed CYP2C9 variants. The formation rate of OH-celecoxib was significantly reduced in CYP 2C9*3 samples, compared to samples with two functional alleles. The CYP2C9*2-samples did not differ from CYP2C9*1 in any...
Depression and suicidal behavior in Uganda : validating the response inventory for stressful life events (RISLE)
(2005-05-11)
Background: Depression and suicide ideation are prevalent in the general
population but their recognition and detection in primary care is
problematic. The present study investigated if the RISLE can be used to
detect ...