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Macrophages : as central inflammatory mediators and as targets for therapeutic interventions
(2006-01-06)
Macrophages (Mphis) are important cellular players in autoimmune pathogenesis, being the most numerous cells infiltrating sites of inflammation and causing much of the associated tissue damage. Apart from these proinflammatory ...
Drug treatment of elderly : the need for changing behaviour among providers and patients
(2004-09-10)
Medication-related illness is a great problem, particularly among the
elderly. Elderly people use many different drugs, they have many diseases
and symptoms, and also experience natural signs of aging. Altogether, ...
Off-label drug treatment and related problems in children : a register-based investigation
(2006-04-21)
Introduction: There is a lack of pediatric documentation concerning efficacy and safety of many drugs, which may contribute to off-label drug treatment and increase the risk for adverse drug reactions (ADRs).
Aims: ...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
of periodontal bone loss of more than 30% of the root length was 3.5-fold and 4.3-fold elevated in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was 7.5-fold elevated in water...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and immunodeficiency, only...
Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue
(2005-10-07)
The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival ...
Regulation of the ribosomal RNA transcription by c-MYC oncoprotein
(2006-11-30)
The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon ...
Chronic infection with chlamydia pneumoniae in COPD and lung cancer
(2005-09-16)
smokers and 7 nonsmokers were studied using a direct immunofluorescence technique for detection of Cpn. Lung tissue from 24 patients with emphysema were tested using immunohistochemistry (MC) for Cpn. Serum samples were available for all patients...
Occupational exposure to pesticides and risk of leukemia among offspring in Costa Rica
(2006-11-03)
Background: Leukemias are the most common childhood cancers, accounting for 25-35% of the incidence of all childhood cancer in most populations. In early reports on cancer, Costa Rica ranks among the highest incidence of ...
Aspects of Helicobacter pylori transmission
(2005-09-30)
The bacterium Helicobacter pylori infects the gastric mucosa of about half of the world's population. The infection causes gastritis and contributes to the development of peptic ulcer disease and gastric cancer. H. pylori ...