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Nitric oxide : a surrogate marker of bowel inflammation
(2005-10-28)
% and specificity of 91 % in discriminating between IBS and active IBD. Rectal levels of NO were correlated to disease activity in patients with IBD or CC and were reduced markedly in IBD patients who responded to treatment. Surprisingly, rectal levels of NO were...
Alzheimer´s disease-related amyloid precursor protein and presenlin genes : normal function and pathophysiology
(2004-10-08)
or sporadic types. A number of genes have mutations that cause the familial forms of AD. These include the amyloid precursor protein (APP) gene and the presenilin (PS) 1 and 2 genes. Also, inheritance of the apolipoprotein E epsilon4 allele confers...
Studies of sterol 12alpha-hydroxylase (CYP8B1) : distribution and role for cholesterol homeostasis and gallstone formation
(2006-05-19)
Bile acids are essential physiological molecules which carry out multiple functions such as facilitating the absorption of dietary lipids and regulating the metabolism of cholesterol and bile acids. The formation of bile ...
Catalytic mechanisms and evolution of leukotriene A4 hydrolyse
(2006-11-10)
of chemical mediators, which by different means control, maintain and resolve the process. One group of such mediators is the leukotrienes, among which LTB4 is found. LTB4 has several immunomodulating properties and mainly acts by recruiting leukocytes...
Transoesophageal and transthoracic recordings of mitral annulus motion
(2006-02-03)
Maximal systolic and diastolic velocities recorded from four sites of the mitral annulus motion (MAM) reflect left ventricular (LV) performance. This thesis focus on factors influencing M-mode derived velocities in healthy ...
Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue
(2005-10-07)
intracranial glioblastoma multiforme has remained at 4-5 % for the last 30 years. The knowledge of the brain tumour biology as well as the biology of the normal brain tissue would help to design new therapeutic strategies and to develop new and less toxic...
Child sexual abuse : disclosure, social support and subjective health in adulthood
(2006-05-19)
Child sexual abuse (CSA) is a known risk factor for ill-health. It is assumed that the health consequences are worse if the abuse has been considered severe or if the child has been exposed to cumulative trauma, e.g. ...
Heart failure : aspects on treatment and prognosis
(2006-05-02)
The aim of this thesis was to describe aspects on treatment and prognosis in heart failure. In paper I, we studied two hundred and seventy-nine hospitalised heart failure patients, and related clinical and demograhic data ...
Regulation of gene transcription by the thyroid hormone receptors
(2006-05-26)
Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha ...
Nitric oxide and evaluation of different treatments in experimental colitis and inflammatory bowel disease
(2006-11-10)
is demonstrated and suggests that this effect is mediated by inhibition of neutrophil migration and activation. The studies show that anti-integrin treatment through rectal administration of anti-α2 or anti-α4 integrin antibodies reduced clinical and histological...