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Regression on high-dimensional predictor space : with application in chemometrics and microarray data
(2004-11-26)
This thesis focuses on regression methodology for prediction and
classification in situations where there are many predictors but limited
number of observations. This situation is common in chemometrics and
microarray ...
Aspects of hepatoduodenal trauma and fluid therapy in hemorrhagic shock
(2006-05-26)
Traumatic injury is the leading cause of death among young adults and children, accounting for 5 million deaths worldwide on an annual basis. In Sweden alone, 2500 individuals succumb to traumatic injuries yearly. Beyond the burden of death...
Penicillin-resistant pneumococci in Sweden : epidemiology and public health response
(2005-12-30)
Since 1996, all identified cases of pneumococci with a MIC for penicillin G > 0.5 mg/L (penicillin resistant pneumococci: PRP) have been registered according to the Swedish Communicable Disease Act. In the same year, an expert committee appointed...
Genetic susceptibility to breast and endometrial cancer
(2004-09-10)
Hormones are central in the carcinogenic process in the breast and in the uterine epithelium. Individual genetically determined variation in the response to hormonal influence may alter susceptibility to breast and endometrial ...
Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine
(2005-05-27)
High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as ...
Follow-up studies of the obstetrical brachial plexus injury
(2006-09-15)
in children/adolescents with C5- lesions. Sixty-eight percent of the children/adolescents with right-sided OBPP were lefthanded. Children with complete OBPP had a more severe disability with impact on grip strength, dexterity and sensibility as well as on some...
PET studies of the serotonin transporter in the human brain
(2006-10-27)
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-chloroacrylonitrile yielded, after expulsion of HCN by refluxing in ethanol, 1-benzyl-4,5,6,7-tetrahydroindole. Formylation and benzylimine formation followed by treatment with TosMIC furnished the desired 2-imidazolyltetrahydroindole....
Incidence and prognosis of differentiated thyroid cancer in Sweden
(2006-01-06)
Non-medullary differentiated thyroid cancer (DTC) is a rare disorder but, nevertheless, among the most common cancers in individuals below 40 years of age. DTC consists of papillary (PTC) and follicular (FTC) thyroid cancer. ...
Distribution of serotonin receptors and transporters in the human brain : implications for psychosis
(2005-04-22)
The serotonin (5-HT) system is thought to be involved in different
psychiatric disorders, including depression and anxiety disorders, and is
a major target for the pharmacological treatment of these conditions. ...