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Migration of molecules in the brain : focus on the extracellular space and the cerebrospinal fluid
(2004-08-27)
of the total amount of 3H-dopamine-derived
compounds described the overall effect of cellular uptake, metabolism and
clearance of the compounds into the microcirculation. These profiles
reached steady state levels after 1-2 hours, generating an equilibrium...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...
Peptic ulcer disease in an adult population : the Kalixanda study – a population-based endoscopic study
(2006-12-21)
Introduction: The pattern of symptoms and perception of disease among
patients seeking care does, due to health care seeking behaviour, most
probably not reflect the true health status in the general population.
Upper ...
Diabetes, physical activity and endometrial cancer
(2006-11-22)
cancer, we identified 16 studies (3 cohort and 13 case-control studies), and found that diabetes was statistically significantly associated with an increased risk of endometrial cancer incidence, (summary RR = 2.10 95% CI= 1.75-2.53). Analysis of 2...
Gene expression in human skeletal muscle : effects of activity, fibre type and inheritance for diabetes
(2006-04-07)
One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin resistance are for example...
Regulation of gene transcription by the thyroid hormone receptors
(2006-05-26)
regulators of cell cycle progression. In Paper I, we identified a putative nTRE in the E2F-1 promoter and showed that TR bound directly to this nTRE. This nTRE was sufficient for TRs to mediate both hormone-independent activation and hormone...
On neck load among helicopter pilots : effects of head worn equipment, whole body vibration and neck position
(2005-09-13)
rotation, 2-3 % of neck flexion, and 1.5-2.5 % of trunk inclination. The use of NVG increased muscle activity in upper neck by 0.5-1.5 % and in lower neck by about 0.5 %. Results with added counterweight were about the same as with NVG. Muscle activity...
Children with high and intermediate imperforate anus : aspects of care and psychosocial effects of the malformation
(2005-10-21)
The overall aim of this thesis was to investigate the experiences of
children with high and intermediate imperforate anus and of their
parents; how they have experienced care and treatment and what
consequences the ...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...
HIV-2 genetic evolution and viral dynamics
(2006-05-03)
HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. However, why this lower viral load is seen is not known. In this thesis we have...