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Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease
(2005-01-07)
harbouring the 670/671 APP Swedish mutation (APPswe), transgenic mice that overexpress human acetylcholinesterase in the brain (hAChE-Tg) and double transgenic mice generated by crossing the two mouse strains (hAChE-Tg//APPswe). The overall aim...
Tuberculosis control in Vietnam : directly observed treatment, short-course (DOTS) : the role of information and education
(2004-11-15)
that of the general population (RR 11.06; 95% Cl 8.2814.77).
Mortality rates for the prolonged cough group were 18.96 for men, 11.85
for women, and 15.33 total. These rates were higher than those in general
population (6.71, 5.12, and 5.87 per 1,000 person...
Physical capacity in individuals with cerebral palsy : problems, needs and resources, with special emphasis on locomotion
(2005-09-09)
with or without walking aids, 35 % reported decreased walking ability, 27 % had never been able to walk, and 9 % had stopped walking.
Study II: Ten children with CP participated in a study comparing two different kinds of walkers (anterior and posterior...
Hantaviruses : animal models, immunology and pathogenesis
(2004-11-18)
Hantaviruses cause two serious and often fatal human zoonotic diseases:
hemorrhagic fever with renal syndrome (HFRS) in Eurasia, and hantavirus
cardiopulmonary syndrome (HCPS) in the Americas. Hantaviruses are
rodent-borne ...
Born too small or too early : effects on blood pressure, renal function and retinal vascularization in adulthood : experimental and clinical studies
(2004-11-12)
Background: Several epidemiological studies the past fifteen years have
suggested a connection between fetal growth retardation and later effects
on adult health, such as an increased arterial blood pressure and type ...
Dynamic magnetic resonance imaging of the breast : imaging features for diagnosis and prognosis of breast cancer
(2004-10-29)
The general aim of the present thesis was to identify and study dynamic
contrast-enhanced magnetic resonance imaging (CE-MRI) features that
contribute to the diagnosis and may help in predicting prognosis in
breast ...
Hormones and breast cancer : aspects on receptor expression and metabolism
(2006-02-17)
Breast cancer is the most common malignancy among women in the western world. Sex steroid hormones are implied as risk factors but endocrine regimens are also used in the therapy of breast cancer. Current knowledge about ...
Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease
(2006-04-06)
carrying the Swedish APP 670/671 mutation (APPswe) and sporadic AD. Significant increases of astrocytes expressing the alpha7 nAChR subunits, along with significant decreases in the levels of alpha7 and alpha4 nAChR subunits on neurons, were detected...
Kinetics of HIV-1 drug resistance mutations in vivo
(2006-03-10)
Antiretroviral therapy (ARV) exert a selective pressure on HIV-1 and may select viral drug resistant strains which have competitive advantage in the presence of the drug. Knowledge about the appearance and disappearance ...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
Background & Aim: Tobacco smoking exerts a harmful effect on the periodontal tissues manifested by periodontal pockets, attachment loss and periodontal bone loss. Current evidences on the effects of tobacco on periodontal ...