Search
Now showing items 1-10 of 138
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment
(2005-11-25)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure is well-known to
disrupt Vitamin A (retinoid) homeostasis in rats, resulting in decreased
hepatic storage, as well as increased metabolism and excretion of
retinoids. The aims of this thesis were...
In vitro and postmortem studies of the brain opioid system : association to opiate dependence
(2006-08-25)
Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a central role in mediating the effects of opiates and related opioid. The interaction between opioids and MOR activate and ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
from the first study was used, but underestimated the ribavirin dose. After dose adjustments a mean dose was 2540 mg/day. Due to anaemia, 2 patients required blood transfusions, twice. 9 patients completed treatment and 9 patients were cured...
Pituitary autoantibodies in endocrine disorders
(2005-09-30)
by immunoblotting. Reactivity to a M, 49 000 pituitary autoantigen was significantly more frequent in patients with idiopathic pituitary hormone deficiency (6/21 (28%) p< 0.05) as well as their relatives (10/35 (28%) p<0.02) compared to control subjects (3/44 (6...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
of the beta2-adrenergic receptor (beta2-AR), such as decreased density of beta2-AR on peripheral blood mononuclear cells (PBMC), serum antibodies against beta2-AR and aberrant distribution of SNPs of codon region within the 02-AR gene. I investigated...
Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance
(2006-09-15)
Type 2 diabetes is characterized by chronic hyperglycemia and develops slowly through stages of early impairments of glucose metabolism. The disease is often associated with obesity, physical inactivity, decreased insulin sensitivity and impaired...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and ...
Capsulotomy in anxiety disorders
(2006-05-26)
. Mean Y-BOCS was 34 preoperatively and dropped to 18 at long-term follow-up (p<0.0001). Only 2 patients achieved remission from OCD without substantial side effects. Several neurosurgical complications related to radiosurgery were reported. Two patients...