Search
Now showing items 1-9 of 9
In vitro and postmortem studies of the brain opioid system : association to opiate dependence
(2006-08-25)
Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a central role in mediating the effects of opiates and related opioid. The interaction between opioids and MOR activate and ...
Chemical genetics and immunomodulation in Salmonella enterica serovar typhimurium infection
(2015-04-08)
Salmonella sp. are versatile bacteria that survive and replicate in a plethora of environmental
niches and hosts, including humans. The illnesses caused by various serovars in humans
range from mild gastroenteritis to ...
Dynamic protein trafficking of the nuclear membrane and peroxisomes
(2009-01-30)
The cell nucleus is enclosed by the nuclear envelope (NE), a double lipid membrane separating the nucleoplasm from the cytoplasm. Transport of macromolecules between the nucleus and the cytoplasm takes places through nuclear ...
The Alzheimer’s disease related gamma-secretase complex : localization and novel interacting proteins
(2010-05-07)
Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the
brain that eventually results in cognitive decline. Characteristic
hallmarks of AD are senile plaques containing the amyloid beta-peptide
(Abeta) ...
Studies on gamma-secretase activity and products
(2010-02-26)
gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein ...
Identification and investigation of gamma-secretase associated proteins from brain
(2012-08-17)
Alzheimer disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. The pathological hallmarks in the AD brain are extracellular deposition of amyloid plaques, mainly composed of the ...
Vitamin D and multiple sclerosis : epidemiological studies on environmental and genetic risk factors
(2016-08-24)
Background: Multiple sclerosis (MS) is an autoimmune inflammatory neurological disease with complex aetiology where the causes are not completely known. The main aim of this thesis was to investigate the influence of vitamin ...
Notch signaling : from receptor cleavage to chromatin remodeling
(2005-10-28)
One of the principal signaling mechanisms that control development of multicellular organisms is the Notch signaling pathway. The transmembrane Notch receptor, presented at the cell surface, interacts with ligand on ...
Molecular studies of the γ-secretase complex : focus on genetic and pharmacological modulation
(2012-09-13)
γ-Secretase is a multi-subunit protease complex, composed of presenilin (PS1 or PS2), Nicastrin, Pen-2 and Aph-1, which generates the Alzheimer disease (AD) related 30-43 amino acid long amyloid β-peptide (Aβ). The complex ...