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Macrophages : as central inflammatory mediators and as targets for therapeutic interventions
(2006-01-06)
studied its role in MS and EAE pathogeneses. Both MS and the animal model EAE was associated with significant up-regulation of HMGB1 and the receptors RAGE, TLR2 and TLR4. Primary microglia could also translocate HMGB1 both upon in vitro and in vivo...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Genetic modification of human natural killer cells and possible applications thereof
(2006-08-25)
Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear cells (PBMCs), IL-2...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Studies on alcoholic liver disease
(2006-11-17)
of alcohol related liver disease. We found that rats had appearance of IgG against rat CYP3A 1 and CYP2E 1 during chronic ethanol feeding We found that patients had reactivity against CYP3A4 and CYP2E I in about 20 to 30% and 10 to 20% of the alcoholic sera...
Methological advances in the examination of the dopamine system in brain
(2005-11-18)
) examination of the interaction between D2/D3 receptors and G proteins in human brain in vitro, (ii) selective visualization of D3 receptors with PET, and (iii) improvement of the accuracy in PET imaging of D2/D3 receptors by correction for partial volume...
Hairdressers : hand eczema, hair dyes and hand protection
(2006-10-06)
for assessment of dermal exposure to permanent hair dyes on hairdressers' hands was developed and validated. The validated hand rinse method was used during hair dyeing in hairdressing salons for assessment of the exposure to p-phenylenediamine (PPD), toluene-2...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
of the beta2-adrenergic receptor (beta2-AR), such as decreased density of beta2-AR on peripheral blood mononuclear cells (PBMC), serum antibodies against beta2-AR and aberrant distribution of SNPs of codon region within the 02-AR gene. I investigated...
Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance
(2006-09-15)
Type 2 diabetes is characterized by chronic hyperglycemia and develops slowly through stages of early impairments of glucose metabolism. The disease is often associated with obesity, physical inactivity, decreased insulin sensitivity and impaired...
Coronary artery bypass surgery without extracorporeal circulation
(2006-03-10)
Introduction: Coronary artery bypass surgery with extracorporeal circulation is associated with a systemic inflammatory response syndrome that contributes to morbidity and mortality. Aortic cross clamping and cardioplegic ...