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Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects
(2006-01-27)
expression were here identified in CYP2B6 and CYP2A6 genes. A novel CYP2B6*16 allele was found to carry two SNPs, 983T>C and 785A>G, and was present in 5 subjects having high plasma concentrations of efavirenz, all of African origin. This allele was found...
Pulmonary tuberculosis in pre-trial detentions in St. Petersburg, Russia
(2006-01-06)
the first 2 years of being in remand prison (SIZO). Therefore, if according to new Federal order (2002), prisoners will be held in remand prison for no more than 6 months, the number of new TB cases will be essentially minimized. This will in turn reduce...
The ins and outs of notch ligands and downstream events
(2006-05-26)
Signaling through the Notch receptor constitutes an evolutionarily conserved pathway important for embryonic development of many organs, including the central nervous system and vasculature, in multicellular animals. The ...
Capsulotomy in anxiety disorders
(2006-05-26)
Background and aim: Anxiety disorders are common and a substantial proportion of patients do not respond to conventional treatments such as SSRIs or CBT. Capsulotomy is a neurosurgical treatment for treatment refractory ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available ...
Physical fitness and overweight in Swedish youths
(2005-03-22)
obese. The total prevalence accordingly being 20.1% (95% CI: 18.3% to 22.0%). This sample proved to be heterogeneous concerning overweight status. When obesity and overweight were combined the highest prevalence (26.6%, 95% CI: 21.2 to 32.7) was found...
Anxiety, exhaustion and depression in relation to periodontal diseases
(2006-03-10)
Periodontal diseases (gingivitis and periodontitis), are inflammatory processes of the gingiva and supporting structures of the teeth induced by a microbial biofilm. In periodontitis this inflammatory process causes tissue ...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...
Renal cell death in urinary tract infections : role of E. coli toxins
(2005-01-28)
) inhibited O6-toxin(s)-induced cell death. Furthermore, incubation with a metabolite of HO-1, carbon monoxide, could counteract the effects of E.coli-toxins. The protection by carbon monoxide was associated with up-regulation of p21 protein expression...
Clinical and economic features of categories of patients in defined populations
(2005-11-18)
This thesis addresses the use of information from health care registers on an individual level, making it possible to elucidate the morbidity and comorbidity patterns in defined populations, and to allocate resources in ...