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Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects
(2006-01-27)
Cytochrome P450s constitute a superfamily of heme-binding monooxygenases that play important roles in the metabolism of endogenous substrates and a wide variety of exogenous substances, such as toxins and drugs, and ...
Combined oral contraceptives : impact on the vulvar vestibular mucosa and pain mechanisms
(2007-08-24)
Objective: The main aim of this thesis was to study the impact of
combined oral contraceptives (COC) on the vulvar vestibular mucosa and
pain mechanisms; in healthy women and in women with provoked
vestibulodynia (former ...
Genetic epidemiological studies of adverse pregnancy outcomes and the role of schizophrenia
(2006-02-24)
The purposes of this thesis were to investigate the importance of genetic and environmental factors in the development of adverse pregnancy outcomes and to investigate the role of schizophrenia as a risk factor for and a ...
Diabetes, metformin and gastric adenocarcinoma
(2021-05-18)
Diabetes may increase the risk and mortality of certain cancers, but its association with gastric adenocarcinoma is not clear. On the other hand, metformin, a first-line treatment for diabetes, may reduce cancer risks and ...
Glutamatergic mechanisms in schizophrenia : role of endogenous kynurenic acid
(2005-11-18)
Kynurenic acid, a tryptohan metabolite synthesised in astrocytes, is an
endogenous antagonist at glutamate receptors, in particular it blocks the
glycine site of the (NMDA)-receptor, and at the a7* nicotinic receptor.
The ...