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Therapeutic myocardial angiogenesis and its pharmacological modulation
(2005-09-30)
Angiogenesis is the formation of new blood vessels induced by the proliferation and migration of endothelial cells. Because angiogenesis is a complex process, therapeutic efficacy may be improved by overexpression of ...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Exhaled nitric oxide in schoolchildren with asthma
(2004-11-19)
Background: The fraction of nitric oxide in exhaled air (FENO) is believed to reflect the degree of allergic inflammation present in the lower airways. The diffusing capacity of NO in the airways (DawNO) and the concentration ...
Optimization of cyclophosphamide therapy based on pharmacogenetics
(2006-11-03)
Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by ...
The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion
(2004-10-01)
Myocardial ischaemia initiates complex severe cellular changes and, after a critical time period, myocardial cell death. Despite that restitution of coronary blood flow is an absolute pre-requisite for tissue survival, ...
Prevention and treatment of hepatitis B virus infection
(2005-05-06)
) boosters in non-responders were retrospectively analysed. Seroprotection was achieved in 1,517/1,840 (82.5%) vaccinees. Among non-responders, two-thirds had no detectable antibodies and one-third had levels of 1-9 IU/L (hypo-responders). In the group...
Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(2004-09-03)
55 patients were used in the experiments. RA and RARS cells showed significantly higher spontaneous initiator (caspase-8 and -9) and effector (caspase-3-like) activities than normal bone marrow (NBM). G-CSF inhibited Fasinduced caspase activity...
Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine
(2005-05-27)
High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as ...
Impaired glucose tolerance in ischemic heart disease
(2005-11-18)
Background: Diabetes mellitus (DM) and impaired glucose tolerance test
(IGT) are well known risk factors for cardiovascular disease (CVD).
Individuals with IGT, a prediabetic state, are asymptomatic during many
years ...
Motivating clinical treatment of obesity : methods, education, supervision and outcome
(2004-11-05)
Obesity has become an important health problem worldwide. It increases
the medical risks and affects daily living. Environmental factors such as
diet and sedentary lifestyle are likely to be the cause. In Sweden, the
number ...