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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Kvinnohälsa i perspektiv : studier med barnmorskor och läkare samt med kvinnor som vårdbrukare : exempel från cervixcancerscreening och obstetrisk vård av omskurna kvinnor
(2005-05-06)
In this thesis two areas of women's health are examined from different
stakeholder perspectives. The areas are cervical cancer screening (CCS;
articles I, III, V) and obstetrical care of circumcised/infibulated ...
The role of adenosine and its receptor subtypes in nociception and neuropathic pain
(2005-05-27)
As neurotransmitter/modulator, adenosine plays an important role in nociceptive processing. Adenosine receptors are G-protein coupled and four receptor subtypes, A1, A2A, A2B and A3 have been identified. It is well established ...
Neurotrophic and immune regulatory factors in neuroinflammation
(2004-10-22)
Inflammatory reactions in the nervous system act as a double-edged sword.
On the one hand, neuroinflammation can have very devastating effects on
the nervous system, leading to neurological dysfunction. Conversely,
there ...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis in vivo. The following...
Diagnostic tests for adiposity and metabolic risk factors in adolescence : results from the Stockholm weight development study (SWEDES)
(2005-03-25)
Background: Despite growing concern about the development of pediatric
obesity, there is still controversy about its classification.
International classification systems have been proposed and national
systems are in ...
Xenobiotics-induced phosphorylations of MDM2
(2006-11-24)
The aim of the present study was to characterize the Mdm2 and p53 responses induced by DNA damaging xenobiotics and how these responses can be modified by non-genotoxic xenobiotics. During control conditions cellular levels ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
viral response was achieved more often in patients with ribavirin concentration above the median concentration of 8.7µM, than below the median. Data are suggesting that higher ribavirin concentrations may lead to better treatment response in genotype 1...
Studies of glucocorticoid receptor interacting proteins
(2005-05-06)
The glucocorticoid receptor (GR) functions as a ligand dependent transcription factor. Nonliganded GR resides mainly in the cytoplasm bound to a complex containing heat shock proteins (hsp). Upon ligand binding, GR dissociates ...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...