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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Genetic modification of human natural killer cells and possible applications thereof
(2006-08-25)
Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear cells (PBMCs), IL-2...
Family history and breast cancer susceptibility : clinical and molecular studies
(2006-09-15)
with a more modest increased risk of the disease. Mutations in the known high risk genes BRCA1, BRCA2 and p53 account for less than 25% of the familial risk for breast cancer, while the remainder remain genetically unexplained despite a large effort...
Diabetes, physical activity and endometrial cancer
(2006-11-22)
cancer, we identified 16 studies (3 cohort and 13 case-control studies), and found that diabetes was statistically significantly associated with an increased risk of endometrial cancer incidence, (summary RR = 2.10 95% CI= 1.75-2.53). Analysis of 2...
On neck load among helicopter pilots : effects of head worn equipment, whole body vibration and neck position
(2005-09-13)
rotation, 2-3 % of neck flexion, and 1.5-2.5 % of trunk inclination. The use of NVG increased muscle activity in upper neck by 0.5-1.5 % and in lower neck by about 0.5 %. Results with added counterweight were about the same as with NVG. Muscle activity...
Epstein-Barr virus nuclear antigen 1, Oct and Groucho/TLE in control of promoter regulation
(2005-11-04)
The human herpes virus Epstein-Barr virus (EBV) is carried by
approximately 95% of the adult population. It can form a lifelong latent
infection in the B-cells by avoiding our immune system. A latent EBV
infection is ...
Regenerative medicine of the airway cartilage : a morphological and immunohistochemical study with focus on cricoid cartilage defects treated with BMP-2
(2005-05-18)
stenosis and tumors of the larynx and thyroid. The BMPs constitute a large family of factors that is part of the transforming growth factor beta superfamily. BMP-2 is a well-known modulator of skeletal patterning and, more specifically, of cartilage...
Modeling the economics of prevention
(2005-04-29)
Cardiovascular disease, particularly coronary heart disease and stroke, is the most common cause of death world wide, with a prevalence that is expected to increase. The consequences of the modern lifestyle such as obesity ...
Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
The aim of this thesis was to elucidate preventable determinants of smoking and smokeless tobacco use in adolescence in the frame of a longitudinal study (BROMS cohort). The study population encompasses 3019 children ...
Muscle mitochondria in sepsis
(2006-11-24)
lactate concentration. The second study relating to this problem was performed in a human model for studying the very early phase of sepsis. In this study leg muscle biopsies were obtained at baseline and 2 and 4 hours after an intravenous endotoxin...