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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Computational exploration of human genome variation
(2004-09-03)
In studies of human genome variation, researchers attempt to identify the DNA sequence differences between our genomes that contribute substantially to variation that can be observed on a physical level (phenotype). Genetic ...
Effect of estrogen on longitudinal bone growth
(2006-04-14)
potential in cultured fetal rat metatarsal bones through selective apoptotic elimination of stem-like chondrocytes (Paper IV). Tamoxifen triggers the Fas/FasL apoptotic pathway and activates the caspases-8, -9 and 3.
This thesis increases our...
Molecular studies of Neisseria : host cell interactions
(2004-08-11)
The Neisseria family includes many non-pathogenic species but also two strict human pathogens; Neisseria gonorrhoeae and Neisseria meningitidis. Both organisms colonise mucosal surfaces and may cause disseminated infections ...
Host responses and bacterial virulence factors in Neisseria infections
(2004-08-27)
Neisseria meningitidis and Neisseria gonorrhoeae are human specific pathogens. N. meningitidis is a major cause of meningitis and sepsis, whilst N. gonorrhoeae causes many millions of cases of gonorrhea in the world every ...
Plasticity in the dopamine 1 receptor system : behavior and cell biological studies
(2004-09-10)
Dopamine is a key neurotransmitter in the brain, and has an important
modulatory role in the control of motor activity and cognitive processes.
Dysfunctions of the dopamine system have been implicated in several
neuro ...
The impact of estrogens on leukocyte function in remodeling of extracellular matrix
(2005-11-23)
enzymes, capable of degrading components of connective tissue. Cervical leukocytes were identified as a source of matrix metalloproteinase-2 and 9, which have collagen IV and proteoglycans as substrates. An increased level of these enzymes in the cervix...
Prevention and treatment of hepatitis B virus infection
(2005-05-06)
) boosters in non-responders were retrospectively analysed. Seroprotection was achieved in 1,517/1,840 (82.5%) vaccinees. Among non-responders, two-thirds had no detectable antibodies and one-third had levels of 1-9 IU/L (hypo-responders). In the group...
Nicotinic transmission and drugs in anesthesia : neuromuscular blocking agents and propofol : consequences for carotid body function
(2006-02-17)
The carotid body is the global oxygen sensor of the human body. Acute hypoxia elicits instant hyperventilation mediated from the carotid body type 1 cells, where nicotinic transmission is a key component in oxygen sensing ...
Matrix metalloproteases and cell motility in malignant mesothelioma
(2004-10-29)
in malignant mesothelioma cells. All investigated mesothelioma cell lines expressed mRNA for MMP-1, MMP-2, MMP-3, MMP-9 and 6/8 cell lines expressed MMP-7, 3/8 cell lines expressed MMP-10. MMP-11 was not detected in any of mesothelioma cell lines tested. MMP-2...