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Nicotinic transmission and drugs in anesthesia : neuromuscular blocking agents and propofol : consequences for carotid body function
(2006-02-17)
The carotid body is the global oxygen sensor of the human body. Acute hypoxia elicits instant hyperventilation mediated from the carotid body type 1 cells, where nicotinic transmission is a key component in oxygen sensing ...
Regulation of the ribosomal RNA transcription by c-MYC oncoprotein
(2006-11-30)
The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon ...
Regulators of angiogenesis in diabetes and tumors
(2005-11-21)
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular ...
The role of the ubiquitin-proteasome system in neurodegenerative disorders
(2006-04-28)
Neurodegenerative disorders are a heterogeneous group of clinically and pathologically diverse diseases. The diseases are characterised by selective loss of neurons. in specific regions of the brain. The result is disruption ...
The ubiquitin-proteasome system during proteotoxic stress
(2006-03-31)
The dual function of the ubiquitin-proteasome system in protein quality control and as a master regulator of vital cellular processes places the system in a delicate position. This might be particularly relevant under ...
New pathogenic mechanisms in diabetic wound healing
(2012-11-01)
Diabetic foot ulcers (DFU) represent one of the most feared and invalidating complication of diabetes with high financial pressure for the healthcare system. For the moment there is no specific therapy available and it has ...
Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling
(2013-09-12)
Angiogenesis is a complexly regulated process activated to assure cells with normal supplies of nutrients and oxygen. Playing such an essential role in the homeostasis of tissues, it is critical to understand its physiology ...
p53 transcriptional activity as a tool to uncover novel and diverse druggable targets in cancer
(2018-05-28)
The transcription factor p53 is one of the most studied tumour suppressors with over 90 000 publications in PubMed referring to the protein. It is also the most frequently mutated gene across all cancer types with around ...