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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Characterization of Eae4 and Eae19-22 in autoimmune neuroinflammation
(2006-02-17)
region to Eae20. These 3 QTLs were mapped on a region spanning 16.8Mb colocalized with several QTLs regulating experimental autoimmune diseases such as Oia2, Pia1 and Cia13. We demonstrated an influence of Eae20 on incidence and severity of EAE while...
Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia
(2006-08-25)
Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult ...
Mechanisms of adaptive mutations in bacteria
(2005-10-07)
Bacteria have the ability to adapt to various challenging environments. The rate, extent and consequences of bacterial adaptation depend on both microbial and environmental factors. This thesis analyses some of the mechanisms ...
The complex genetics of experimental autoimmune neuroinflammation
(2004-11-15)
of these regions using an advanced intercross line (AIL) between DA and PVG.1AV1 in the 7th and 10th generations. AIL mapping proved to be an efficient approach i) to narrow down QTLs, ii) to resolve adjacent QTLs, and iii) to detect epistatic interactions between...
Spontaneous correction of fracture deformity : a study in the rat
(2004-11-12)
mineral uptake
studies showing intense mineralization, i.e., bone formation, from day 7
to 35 on the concave side of the fracture, while on the convex side bone
resorption predominated.
Site-specific differences in local bone turnover, e.g., to correct...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Pleurodesis in chronic effusions : studies on inflammatory mediators, respiratory function, predictability of treatment outcome, drug efficiency and survival after treatment
(2004-09-17)
Metastatic or primary (mesothelioma) malignancy of the pleura often
generates major pleura] effusion, giving respiratory distress and low
quality of life to the patients. Evacuation of fluid by thoracocentesis
gives ...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
)] and 841 woman [mean age = 35.7 years (±2.9 SD)] who participated in an epidemiological study of periodontal health that was started in 1985, 2.4 % were found to exhibit foetor ex ore and 1 % were diagnosed as having halitophobia. Subjects with both...
Patient-orientated aspects of the postoperative course after hernia surgery
(2006-09-01)
submitted to 1643 patients recorded in the hernia register during 2 consecutive months in 2002. The response rate was 88% (1448 patients). The most common complications recorded were haematoma in 203 (14%) patients, severe pain in 168 (12%) patients...