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Spontaneous correction of fracture deformity : a study in the rat
(2004-11-12)
The aim of the present study was to elaborate a model in the rat
permitting analysis of bone modeling to correct fracture deformity. Among
conceivable regulators of this process, the study focused on the
peripheral ...
Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease
(2005-11-04)
Alzheimer's disease (AD) is the most common cause of dementia and a
growing health care problem worldwide. The disease affects different
brain regions, including hippocampus, enthorhinal cortex, amygdala,
neocortex and ...
Mechanisms influencing natural killer cell recognition of tumour cells
(2016-04-12)
Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK ...
Fluoride and health : epidemiological studies of fluoride exposure and hip fracture, myocardial infarction and osteosarcoma
(2016-10-07)
The aim of this thesis was to investigate the association between drinking water fluoride exposure and risk of hip fracture, myocardial infarction, and osteosarcoma. Swedish nation- wide population-based registers have ...
Epigenic regulation and posttranslational modification of human cytochrome P450s : focus on CYP2W1, CYP1A2 and CYP2C18
(2008-11-21)
The cytochrome P450 superfamily represents a very important group of
enzymes that are responsible for the metabolism of drugs as well as of
endogenous compounds. Many P450s are genetically polymorphic causing
important ...
Ovarian response to vascular and toxic insults in early life : focus on ovarian reserve and fertility preservation
(2020-05-08)
The ovarian reserve is defined as the number of eggs embodied in primordial follicles. Every woman is born with a fixed number of primordial follicles, which are formed during fetal development. Pathological events can ...
Immunomodulation and its effector mechanisms in atherosclerosis
(2007-05-11)
Atherosclerosis is a disease of the arterial intima, characterized by
cholesterol deposition, inflammation and fibrosis. The pathogenesis of
atherosclerosis is related to both innate and adaptive immune responses,
and ...
Neck and shoulder pain : prevalence, incidence and risk factors : the IKCo cohort study
(2008-09-02)
This thesis presents the results of the prevalence and the incidence of
neck/shoulder pain (NSP) and its risk factors in an industrial population
based cohort study. The project was completed between 2003 and 2007 in
Iran ...
Drug resistance in acute myeloid leukemia : clinical and experimental studies
(2008-11-07)
The long-term result of chemotherapy in acute myeloid leukemia (AML) is
poor, even though a majority of AML patients initially respond to
chemotherapy and achieve complete remission (CR). Initially resistant
disease as ...
Methological advances in the examination of the dopamine system in brain
(2005-11-18)
The dopamine (DA) system in brain has attracted considerable attention in neuroscience due to its involvement in fundamental brain functions and its postulated role in the pathophysiology of several neuropsychiatric ...