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Polymyositis and dermatomyositis : inflammation, muscle structure and immunosuppressive treatment
(2012-05-24)
Polymyositis and dermatomyositis are chronic, inflammatory disorders characterized by muscle weakness, low muscle endurance and by inflammation in skeletal muscle tissues. The pathogenesis is not completely understood and ...
Suicide mortality in the South African context : exploring the role of social status and environmental circumstances
(2005-11-28)
Suicide is a serious public health problem worldwide, but is differentially distributed across social groups and regions. The goal of this thesis, focusing on the post-apartheid transitional setting of South Africa, is to ...
Pain, mechanisms of fatigue and autonomic function in rheumatoid arthritis
(2016-11-14)
Rheumatoid arthritis (RA) is a disabling chronic autoimmune disease characterized by joint pain, and potentially leading to a serious decay of life quality. Pain remains the most important problem for patients with RA, and ...
Long-term sickness absence : aspects of society, work, and family
(2010-04-01)
Sickness absence has varied considerably in Sweden over time and
increased substantially between 1997 and 2002, especially among women.
The composition of such absence has also changed in that there have been
increases ...
Molecular mechanisms of mammalian mitochondrial DNA replication and transcription
(2009-02-20)
Mitochondria are cytoplasmic organelles in eukaryotic cells, mainly devoted to the synthesis of ATP, through the Oxydative Phospshorylation System (OXPHOS). The organelle has its own genome, the mitochondrial DNA (mtDNA) ...
Anti-gene oligonucleotides : DNA binding and therapeutic application
(2021-10-01)
The field of nucleic acid therapeutics has in the last decade experienced substantial growth. This is evident from a multitude of new publications, an increasing number of clinical trials and several approved therapeutics ...
Perioperative glucose control
(2018-04-04)
Trauma or surgery elicit a physiological stress response, which among others induces insulin resistance. It could be described as a state where the biological response to a given dose of insulin is reduced, and is associated ...
Chronic dysglycaemia and diabetes type : impact in critical illness and sepsis
(2022-09-19)
Diabetes is a common disease in the general population. Higher susceptibility to infection and increased morbidity can lead to severe illness and intensive care unit (ICU) admission. Glycated haemoglobin A1c (HbA1c), a ...
Burnout: a matter of impaired recovery?
(2012-01-13)
The general aim of this thesis work was to investigate physiological and subjective markers of recovery from stress in order to identify and discuss possible risk factors precipitating burnout, as well as factors related ...
Exploring childhood apraxia of speech : speech and language profiles in 5-year-olds with suspected apraxia of speech or cleft palate
(2020-05-04)
Introduction and aims: Childhood apraxia of speech (CAS) is a speech sound disorder (SSD) lacking a quantifiable measure discriminating all cases of CAS from other SSDs. This project aimed at exploring CAS using different ...