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Radiological imaging of pulmonary emphysema : preoperative evaluation of candidates for lung volume reduction surgery
(2002-05-07)
Lung volume reduction surgery (LVRS) for pulmonary emphysema, first described by Brantigan in 1957, was re-introduced by Cooper et al in 1995. From a surgical point of view, information on the extent and distribution of ...
Hereditary colorectal cancer : predisposition and prevention
(2004-01-23)
This thesis focuses on the clinical results from a ten-year long
follow-up surveillance program, including regular colonoscopy, for
subjects (n=304, 780 colonoscopies) with increased risk of colorectal
cancer, and on ...
Myocardial protection by hyperoxia
(2002-05-02)
Oxygen is essential for normal respiration in aerobic organisms, and prolonged deficit of oxygen always has detrimental consequences.However, all aerobic life forms are faced with the threat of oxidation from molecular ...
Genetic and experimental studies of seasonal affective disorder and related phenotypes
(2003-03-14)
Seasonal affective disorder (SAD) is a subtype of recurrent depressive or bipolar disorder, in which episodes reoccur and remit during a particular season each year. A genetic component in vulnerability to winter SAD has ...
A functional genomics approach to study prostate disorders
(2003-09-12)
Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are the two most common prostatic disorders in elderly man. Currently, the causes of both diseases are still not clear. However, androgen is a well recognized ...
Pulmonary embolism : validation of diagnostic imaging methods in the clinical setting
(2002-09-20)
Pulmonary embolism (PE) is an elusive diagnosis and none of the existing imaging modalities have a 100% diagnostic specificity or sensitivity. Pulmonary arteriography (PA) is the most specific test although the improvement ...
Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide
(2003-03-07)
In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes ...
Genetic factors influencing susceptibility to intracellular infections
(2002-05-15)
Genetics of susceptibility to infection is a complex trait in which many factors from the host, the parasite and the environment, interact to produce different clinical manifestations of disease.
This thesis explores ...
Cryptic chromosome abnormalities in idiopathic mental retardation
(2001-12-21)
Mental retardation is a common disorder, affecting 1-3% of the population. In spite of improved diagnostic tools, the etiology can still not be established in half of the cases. Several lines of evidence indicate a genetic ...
Studies of polyglutamine repeats and their biology in relation to disease
(2001-08-23)
polyglutamines. Our study
provided evidence against the hypothesis that a large CAG repeat
expansion is the basis of SPG4. This has now been confirmed by the
cloning of the gene. In paper IV, eight spinocerebellar ataxia type 7
(SCA7) families with marked...