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Chromatin remodelling and gene regulation
(2001-04-06)
the glucocorticoid antagonists RU43044 and RU486. Hormone-induced transcription from the MMTV promoter was inhibited by both antagonists. This resulted in almost complete loss of translational nucleosome positioning and reversal of chromatin structure...
A functional genomics approach to study prostate disorders
(2003-09-12)
Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are the two most common prostatic disorders in elderly man. Currently, the causes of both diseases are still not clear. However, androgen is a well recognized ...
Chromatin structure and histone modifications in gene regulation
(2006-11-24)
In the living cell, DNA is densely packed into a chromatin structure constituting nucleosomal arrays. One nucleosome core particle includes a disc shaped protein octamer consisting of pairs of histones H2A, H2B, H3 and H4. ...
Diabetes mellitus and the risk of dementia
(2008-04-25)
This doctoral thesis investigated the complex relationship between
diabetes and the risk of dementia, Alzheimer's disease (AD) and vascular
dementia (VaD), and examined the effect of borderline diabetes on the
risk of ...
Wnt signaling in early brain development and disease
(2014-10-21)
Wnt/Planar Cell Polarity (PCP) signaling is involved in many cellular processes throughout the development of the embryo. These include control of proliferation, differentiation, migration and cell fate decisions. Deregulation ...
Transcription factor effects on chromatin organisation and gene regulation
(2005-09-16)
The intranuclear DNA of all eukaryotic cells is packed into chromatin, generating a repressive environment for the genome. Remodelling of the local chromatin structure is a vital process that allows access to the obscured ...
Elderly Iranians in Sweden : the impact of migration on risk factors for cardiovascular disease
(2008-03-14)
Aim: To analyze determinants of and differences in risk factors for cardiovascular disease (CVD) among elderly Iranians in Sweden, elderly Swedes, and elderly Iranians in Iran.
Method: A total of 1212 men and women ...
Molecular methods in malaria control in the era of pre-elimination
(2015-03-03)
Increased funding combined with effective malaria control methods for prevention, diagnosis, and treatment, has resulted in a 30% reduction of the global malaria burden over the last decade. As malaria prevalence declines ...