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Endothelin and nitric oxide in the fetoplacental circulation
(2004-05-21)
Background: Normal fetal growth and development depend on a satisfactory uteroplacental and fetoplacental blood flow. This will ensure an adequate gaseous exchange and nutritional supply to the fetus. The importance of ...
Rectal cancer : staging, radiotherapy and surgery
(2003-05-02)
In Sweden, about 1800 patients are annually diagnosed with adenocarcinoma of the rectum. Surgery remains the major primary treatment. Adjuvant radiotherapy and total mesorectal excision (TME) are two major achievements in ...
Pharyngeal function, airway protection and anesthetic agents
(2002-04-17)
Anesthesia related complications occur most frequently in the immediate postoperative period. The three most common conditions associated with such events are ventilatory failure, airway obstruction and aspiration. The ...
Development of a novel methodology for the synthesis of oligonucleo-peptide conjugates
(2004-05-20)
with the very acid-sensitive nucleic acid backbone. A new masking group (the 2,6-Dmbz) for the imidazole function of histidine was developed, which provided synthesis of peptides in good yields and with very limited racemization. This combination of protecting...
Intravasal microdialysis as a novel technique to monitor metabolism in myocardial ischemia and critical illness
(2003-05-07)
Rapid detection of post-operative myocardial ischemia is of great value in the treatment of patients undergoing cardiac surgery. With the methods readily available in modem thoracic intensive care units post-operative ...
Purification, structure and function of bioactive peptides
(2004-04-02)
by an isopeptide bond. In addition, NT(2-13) and NT(3-13) together with a fragment (22-38) of dopamine- and adenosine 3 ,5 -monophosphate-regulated phosphoprotein (DARPP-32) were also detected and studied by MALDI MS and Edman degradation. All the NT forms were...
Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism
(2001-11-21)
Human immunodeficiency virus type 2 (HIV-2) is the second virus that
causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and
similar genetic organisation and biological properties, but the two
viruses are distinguished certain...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release
(2003-05-23)
Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic beta...
Circulating immune complexes in atherosclerotic vascular disease
(2001-08-31)
were evident within one
week in four young patients subjected to a 2-week elimination diet
followed by challenge with the alimentary antigen in question.
Elevated levels of CICs were present in patients with premature
peripheral atherosclerosis...