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Pregnancy related risk factors for breast cancer
(2003-12-19)
Pregnancies offer a life-long reduction in breast cancer risk. It has
repeatedly been shown that both number of pregnancies and age at first
birth affect the future breast cancer risk. The mechanisms for this
protection ...
Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene
(2003-05-23)
for the AhR is the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The present study was undertaken in an attempt to elucidate the mechanism of activation of the CYP1A1 gene by several compounds that recently have been reported...
Langerhans cell histiocytosis : a clinical and immunological study
(2003-02-21)
Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, eosinophilic granuloma, Hand-Schüller-Christian or Letterer-Siwe disease, is a rare disease with a reported incidence in childhood of 5.4 cases per ...
Women’s expectations and experience of care during pregnancy and childbirth
(2003-10-03)
on antenatal care. The majority of the 3,061 women, who completed the first questionnaire, wanted to follow the standard visiting schedule, while 23 per cent preferred more visits and seven per cent preferred fewer visits. The continuity of caregiver was highly...
In silico prediction of CIS-regulatory elements
(2004-04-19)
As one of the most fundamental processes for all life forms, transcriptional regulation remains an intriguing and challenging subject for biomedical research. Experimental efforts towards understanding the regulation of ...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Mild cognitive impairment neuroimaging markers for early diagnosis of dementia
(2003-09-12)
This thesis concerns the investigation of mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single photon emission computed tomography (SPECT) and quantitative electroencepholography (qEEG).
In study ...
Studies on the inflammatory response in experimental acute pyelonephritis and its importance for the development of renal scarring
(2002-01-08)
antagonist, losartan, the same experimental model was used. Mice treated with losartan showed a marked reduction of TGF-beta mRNA expression and protein secretion compared to saline treated controls. A 50% reduction in cortical scarring was also observed at 3...
Risk characterization of familial cancer using the Swedish family-cancer database with a special reference to breast cancer
(2003-11-07)
the usual risk when one of the parents had cancer, if both parents had cancer, the risk was 1.3-1.4 times higher. When offspring cancer risk was analyzed by index cancer, same as in parent, the risk elevated to 2-3 times for many cancer sites like colorectum...