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Modulation of bile acid and cholesterol metabolism in health and disease
(2004-05-07)
An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis ...
The p53-induced gene wig-1 : regulation of expression and role in embryonic development
(2003-11-21)
The p53 tumor suppressor is a transcription factor that responds to various forms of cellular stress. Activated p53 induces growth arrest or apoptosis through transcriptional regulation of a wide range of target genes. ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. ...
Local recurrence after breast conserving surgery in breast cancer
(2002-08-30)
. Generally, the risk of local recurrence was higher than expected, but the estimated survival rates were gratifying. The overall risk of local recurrence was 9.2% at five years and 21.1% at ten years, and the breast cancer-specific survival was 93.3% and 85...
Allergic inflammation in children with pet allergy and asthma : mechanisms, markers and clinical consequences
(2002-05-10)
Immunological background: Allergic inflammation is a multiple-step process with many actors, where eosinophils and the release of their granula proteins play an important role. The recruitment of eosinophils is a crucial ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
in most malignant human tumors. Most intriguingly, both p53 and Rb proteins are in part regulated through the CDKN2A (INK4a/ARF) locus on human chromosome 9p21, a region frequently lost in tumors. This region encodes two structurally and functionally...
Molecular characterisation of major allergens from mite (Lep d 2) and cat (Fel d 1)
(2004-05-14)
The prevalence of allergic disease has increased significantly during the last decades and today more than 30% of the Swedish population is affected. By using recombinant allergens, diagnostics and treatment can be improved ...
Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention
(2003-11-14)
Cisplatin is an anticancer drug used against a number of malignancies e.g. testicular cancer, ovarian cancer and some paediatric malignancies. The main dose limiting side effects of cisplatin are oto- and neurotoxicity. ...
Intestinal functions in animals : an experimental study on horses, pigs, cows and fish
(2001-11-07)
Animals and humans live in symbiosis with an active gastrointestinal
ecosystem. The balance of the system is maintained by the main actors,
the macroorganism, the microflora and the environment, in concert.
Microflora ...